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J-GLOBAL ID：201902240305902508   Reference number：19A2617243

Development of a Water-Soluble Indolylmaleimide Derivative IM-93 Showing Dual Inhibition of Ferroptosis and NETosis

フェロトーシスとネトシスの二重阻害を示す水溶性インドリルマレイミド誘導体IM-93の開発【JST・京大機械翻訳】

Author (19)： Dodo Kosuke (Synthetic Organic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Saitama, Japan) ,  Dodo Kosuke (Sodeoka Live Cell Chemistry Project, ERATO, JST, Saitama, Japan) ,  Dodo Kosuke (Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Miyagi, Japan) ,  Kuboki Erika (Laboratory of Immune Regulation, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan) ,  Shimizu Tadashi (Synthetic Organic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Saitama, Japan) ,  Shimizu Tadashi (Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Miyagi, Japan) ,  Imamura Ryu (Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University, Ishikawa, Japan) ,  Magarisawa Megumi (Laboratory of Immune Regulation, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan) ,  Takahashi Masahiro (Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Miyagi, Japan) ,  Tokuhiro Takuto (Laboratory of Immune Regulation, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan) ,  Yotsumoto Satoshi (Laboratory of Immune Regulation, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan) ,  Asano Kenichi (Laboratory of Immune Regulation, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan) ,  Nakao Shuhei (Synthetic Organic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Saitama, Japan) ,  Terayama Naoki (Synthetic Organic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Saitama, Japan) ,  Suda Takashi (Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University, Ishikawa, Japan) ,  Tanaka Masato (Laboratory of Immune Regulation, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan) ,  Sodeoka Mikiko (Synthetic Organic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Saitama, Japan) ,  Sodeoka Mikiko (Sodeoka Live Cell Chemistry Project, ERATO, JST, Saitama, Japan) ,  Sodeoka Mikiko (Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Miyagi, Japan)
Material： ACS Medicinal Chemistry Letters
Volume： 10  Issue： 9  Page： 1272-1278  Publication year： 2019 
JST Material Number： W5043A  ISSN： 1948-5875  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： The indolylmaleimide (IM) deri...

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Thesaurus term： *water solubility ,  *twist drill ,  oxidative stress ,  rat ,  cell death ,  lipid peroxidation ,  necrosis
Semi thesaurus term： 阻害剤 ,  ピロトーシス ,  構造活性相関研究 ,  阻害活性 ,  心臓保護 ,  再潅流障害 , 【Automatic Indexing@JST】

Author keywords (5)： Indolylmaleimide ,  necrosis ,  cell death ,  ferroptosis ,  NETosis

JST classification (3)： Structure-activity relationship of drugs  (GV01050B) ,  Receptors on cell membrane  (EF04030C) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Terms in the title (7)： フェロトーシス ,  阻害 ,  水溶性 ,  ドリル ,  マレイミド誘導体 ,  IM ,  開発