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J-GLOBAL ID：201902240585102657   Reference number：19A0633221

In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids

ヒト誘導多能性幹細胞由来肺胞組織を用いたHermansky-Pudlak症候群2型のin vitro疾患モデリング【JST・京大機械翻訳】

Author (18)： Korogi Yohei (Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan) ,  Gotoh Shimpei (Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan) ,  Gotoh Shimpei (Department of Drug Discovery for Lung Diseases, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan) ,  Ikeo Satoshi (Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan) ,  Yamamoto Yuki (Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan) ,  Sone Naoyuki (Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan) ,  Tamai Koji (Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan) ,  Konishi Satoshi (Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan) ,  Nagasaki Tadao (Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan) ,  Matsumoto Hisako (Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan) ,  Ito Isao (Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan) ,  Chen-Yoshikawa Toyofumi F. (Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan) ,  Date Hiroshi (Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan) ,  Hagiwara Masatoshi (Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan) ,  Asaka Isao (Department of Fundamental Cell Technology, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan) ,  Hotta Akitsu (Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan) ,  Mishima Michiaki (Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan) ,  Hirai Toyohiro (Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan)
Material： Stem Cell Reports
Volume： 12  Issue： 3  Page： 431-440  Publication year： 2019 
JST Material Number： W3132A  ISSN： 2213-6711  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： It has been challenging to gen...

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Thesaurus term： visualization ,  lysosome ,  cell organelle ,  *human(primates) ,  dysfunction ,  *pluripotent stem cell ,  gene ,  recessive ,  *modeling ,  culture(biology) ,  autosome ,  *pulmonary alveolus ,  lung disease ,  *in vitro experiment
Semi thesaurus term： 生細胞イメージング , 【Automatic Indexing@JST】

Author keywords (10)： iPSC ,  Hermansky-Pudlak syndrome ,  HPS ,  lamellar body ,  alveolar type 2 cell ,  pulmonary surfactant ,  pluripotent stem cell ,  pulmonary fibrosis ,  alveolar organoid ,  MX35

JST classification (4)： Congenital diseases,deformities in general.  (GD03010V) ,  Basic medicine on respiratory system  (GI01020H) ,  Basic medicine on cardiovascular system  (GJ01020K) ,  Skin diseases  (GF03000Q)

Terms in the title (8)： ヒト ,  誘導 ,  多能性幹細胞 ,  肺胞 ,  組織 ,  症候群 ,  疾患 ,  モデリング