Art

J-GLOBAL ID：201902241803411461   Reference number：19A0873301

Enhancer adoption caused by genomic insertion elicits interdigital Shh expression and syndactyly in mouse

ゲノム挿入によって引き起こされるエンハンサーの採用はマウスにおけるinterdigitalshh発現とsyndactylyを誘発する【JST・京大機械翻訳】

Author (6)： Mouri Kousuke (Mammalian Genetics Laboratory, Genetic Strains Research Center, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan) ,  Sagai Tomoko (Mammalian Genetics Laboratory, Genetic Strains Research Center, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan) ,  Maeno Akiteru (Mammalian Genetics Laboratory, Genetic Strains Research Center, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan) ,  Amano Takanori (Mammalian Genetics Laboratory, Genetic Strains Research Center, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan) ,  Toyoda Atsushi (Comparative Genomics Laboratory, Center for Information Biology, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan) ,  Shiroishi Toshihiko (Mammalian Genetics Laboratory, Genetic Strains Research Center, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 115  Issue： 5  Page： 1021-1026  Publication year： 2018 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Acquisition of new cis-regulat...

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Thesaurus term： promoter (genetics) ,  osteogenic factor ,  morphology ,  Cell Death ,  *genome ,  *Mus musculus ,  sintering ,  Web (information system) ,  transgenic mouse ,  Mutation ,  Phenotype ,  overexpression ,  Chordin ,  Gene Expression Regulation ,  Cas9 protein ,  *Myomorpha ,  Heredity
Semi thesaurus term： genetic regulation ,  Cas9 , 【Automatic Indexing@JST】

Author keywords (5)： enhancer adoption ,  genomic insertion ,  Hammer toe ,  Shh ,  interdigital web

JST classification (1)： Structure and chemistry of genes  (EC02020U)

Terms in the title (5)： ゲノム ,  採用 ,  マウス ,  発現 ,  誘発