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J-GLOBAL ID：201902242105087482   Reference number：19A2170369

A case of anti-titin antibody positive nivolumab-related necrotizing myopathy with myasthenia gravis

抗横紋筋抗体陽性の重症筋無力症合併ニボルマブ関連壊死性ミオパチーの1例

Author (6)： ISAMI AIKO (長岡赤十字病院神経内科) ,  UCHIYAMA AYAKA (長岡赤十字病院神経内科) ,  SHIMAOKA YUICHI (長岡赤十字病院呼吸器内科) ,  SUZUKI SHIGEAKI (慶應義塾大学医学部神経内科) ,  KAWACHI IZUMI (新潟大学脳研究所神経内科) ,  FUJITA NOBUYA (長岡赤十字病院神経内科)
Material： 臨床神経学(Web)  (Clinical Neurology (Web))
Volume： 59  Issue： 7  Page： 431-435(J-STAGE)  Publication year： 2019 
JST Material Number： U0602A  ISSN： 1882-0654  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： squamous cell carcinoma ,...
Semi thesaurus term： steroid hormone therapy ,...

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Author keywords (10)： ニボルマブ ,  免疫関連有害事象 ,  重症筋無力症 ,  ミオパチー ,  抗横紋筋抗体 ,  nivolumab ,  immune-related adverse events (irAE) ,  myasthenia gravis ,  myopathy ,  anti-striated muscle antibody

JST classification (3)： Musculoskeletal diseases  (GG03000T) ,  Clinical application of antitumor(=antineoplastic)drugs  (GW16020L) ,  Poisoning in general  (GD06010Q)

Reference (14)：

• 1) Sharma P, Allisom JP. The future of immune checkpoint therapy. Science 2015;348:56-61.
• 2) Naidoo J, Page DB, Li BT, et al. Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. Ann Oncol 2015;26:2375-2391.
• 3) Weber JS, Postow M, Lao CD, et al. Management of adverse events following treatment with anti-programmed death-1 agents. Oncologist 2016;21:1230-1240.
• 4) Kao JC, Liao B, Markovic SN, et al. Neurological complications associated with anti-programmed death 1 (PD-1) antibodies. JAMA Neurol 2017;74:1216-1222.
• 5) Touat M, Talmasov D, Ricard D, et al. Neurological toxicities associated with immune-checkpoint inhibitors. Curr Opin Neurol 2017;30:659-668.

Terms in the title (6)： 横紋筋 ,  抗体 ,  重症筋無力症 ,  合併 ,  ニボルマブ ,  壊死性ミオパチー