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J-GLOBAL ID：201902242235346803   Reference number：19A1475263

Using Spontaneous Eye-blink Rates to Predict the Motor Status of Patients with Parkinson’s Disease

Parkinson病患者の運動状態を予測するための自発的瞬目率の使用

Author (10)： Iwaki Hirotaka (Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, Japan) ,  Sogo Hiroyuki (Faculty of Law and Letters, Ehime University, Japan) ,  Morita Haruhiko (EdiGENE Corporation, Japan) ,  Nishikawa Noriko (Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, Japan) ,  Ando Rina (Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, Japan) ,  Miyaue Noriyuki (Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, Japan) ,  Tada Satoshi (Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, Japan) ,  Yabe Hayato (Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, Japan) ,  Nagai Masahiro (Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, Japan) ,  Nomoto Masahiro (Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, Japan)
Material： Internal Medicine (Web)  (Intern Med (Web))
Volume： 58  Issue： 10  Page： 1417-1421(J-STAGE)  Publication year： 2019 
JST Material Number： U0033A  ISSN： 1349-7235  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： Disease Management ,...

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Author keywords (5)： Parkinson’s disease ,  blink ,  motor fluctuations ,  wearable electronic device ,  wearing-off: dyskinesia

JST classification (1)： Neurologic diagnosis  (GN02000H)

Substance index (2)： Dopamine ,  L-Dopa

Reference (19)：

• 1. Contin M, Martinelli P. Pharmacokinetics of levodopa. J Neurol 257: S253-S261, 2010.
• 2. Astarloa R, Mena MA, Sánchez V, de la Vega L, de Yébenes JG. Clinical and pharmacokinetic effects of a diet rich in insoluble fiber on parkinson disease. Clin Neuropharmacol 15: 375-380, 1992.
• 3. Doi H, Sakakibara R, Sato M, et al. Plasma levodopa peak delay and impaired gastric emptying in Parkinson's disease. J Neurol Sci 319: 86-88, 2012.
• 4. Iwaki H, Nishikawa N, Nagai M, et al. Pharmacokinetics of levodopa/benserazide versus levodopa/carbidopa in healthy subjects and patients with Parkinson's disease. Neurol Clin Neurosci 3: 68-73, 2014.
• 5. Karson CN, Burns RS, LeWitt PA, Foster NL, Newman RP. Blink rates and disorders of movement. Neurology 34: 677-678, 1984.

Terms in the title (5)： Parkinson病 ,  患者 ,  運動 ,  予測 ,  瞬目