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J-GLOBAL ID：201902243045580972   Reference number：19A1588329

Disruption of Otoferlin Alters the Mode of Exocytosis at the Mouse Inner Hair Cell Ribbon Synapse

マウス内有毛細胞リボンシナプスにおけるエキソサイトーシスのモードを変化させるオトフェリンの破壊【JST・京大機械翻訳】

Author (12)： Takago Hideki (Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Gottingen, Gottingen, Germany) ,  Takago Hideki (Department of Rehabilitation for Sensory Functions, Research Institute, National Rehabilitation Center for Persons with Disabilities, Saitama, Japan) ,  Takago Hideki (Collaborative Research Center 889 Cellular Mechanisms of Sensory Processing, Gottingen, Germany) ,  Oshima-Takago Tomoko (Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Gottingen, Gottingen, Germany) ,  Oshima-Takago Tomoko (Department of Rehabilitation for Sensory Functions, Research Institute, National Rehabilitation Center for Persons with Disabilities, Saitama, Japan) ,  Oshima-Takago Tomoko (Collaborative Research Center 889 Cellular Mechanisms of Sensory Processing, Gottingen, Germany) ,  Oshima-Takago Tomoko (Gottingen Graduate School for Neurosciences and Molecular Biosciences, University of Gottingen, Gottingen, Germany) ,  Moser Tobias (Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Gottingen, Gottingen, Germany) ,  Moser Tobias (Collaborative Research Center 889 Cellular Mechanisms of Sensory Processing, Gottingen, Germany) ,  Moser Tobias (Gottingen Graduate School for Neurosciences and Molecular Biosciences, University of Gottingen, Gottingen, Germany) ,  Moser Tobias (Auditory Neuroscience Group, Max Planck Institute for Experimental Medicine, Gottingen, Germany) ,  Moser Tobias (Synaptic Nanophysiology Group, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany)
Material： Frontiers in Molecular Neuroscience (Web)
Volume： 11  Page： 492  Publication year： 2018 
JST Material Number： U7082A  ISSN： 1662-5099  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Sound encoding relies on Ca<su...

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Thesaurus term： gene ,  Cell Membrane ,  multiphase ,  neuron ,  *phosphorus ,  *hair cell ,  monophase ,  Potassium ,  *Exocytosis ,  *synapse ,  secretion (physiology) ,  electric potential ,  Proteins ,  *Ribbon synapse ,  *Hair Cells, Auditory, Inner ,  Endomembrane system

Author keywords (8)： auditory ,  cochlea ,  hair cell ,  spiral ganglion neuron ,  ribbon synapse ,  otoferlin ,  calcium ,  EPSC

JST classification (2)： Central nervous system  (EJ12030F) ,  Biological function  (EB03040U)

Reference (48)：

• Beutner D., Moser T. (2001). The presynaptic function of mouse cochlear inner hair cells during development of hearing. J. Neurosci. 21 4593-4599. doi: 10.1523/JNEUROSCI.21-13-04593.2001
• Chapochnikov N. M., Takago H., Huang C. H., Pangršič T., Khimich D., Neef J., et al (2014). Uniquantal release through a dynamic fusion pore is a candidate mechanism of hair cell exocytosis. Neuron 83 1389-1403. doi: 10.1016/j.neuron.2014.08.003
• Duncker S. V., Franz C., Kuhn S., Schulte U., Campanelli D., Brandt N., et al (2013). Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells. J. Neurosci. 33 9508-9519. doi: 10.1523/JNEUROSCI.5689-12.2013
• Glowatzki E., Fuchs P. A. (2002). Transmitter release at the hair cell ribbon synapse. Nat. Neurosci. 5 147-154. doi: 10.1038/nn796
• Goodman M. B., Lockery S. R. (2000). Pressure polishing: a method for reshaping patch pipettes during fire polishing. J. Neurosci. Methods 100 13-15. doi: 10.1016/S0165-0270(00)00224-7

Terms in the title (5)： マウス ,  内有毛細胞 ,  リボンシナプス ,  エキソサイトーシス ,  破壊