Art

J-GLOBAL ID：201902244038229454   Reference number：19A1288822

Presenilins and γ-Secretase in Membrane Proteostasis

膜蛋白質におけるプレセニリンとγ-セクレターゼ【JST・京大機械翻訳】

Author (2)： Oikawa Naoto (Department of Neurology, University of Bonn, 53127 Bonn, Germany) ,  Walter Jochen (Department of Neurology, University of Bonn, 53127 Bonn, Germany)
Material： Cells (Web)
Volume： 8  Issue： 3  Page： 209  Publication year： 2019 
JST Material Number： U7155A  ISSN： 2073-4409  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The presenilin (PS) proteins e...

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Thesaurus term： lysosome ,  clearance ,  subunit ,  homeostasis ,  Metabolism ,  complex (substance) ,  *Proteins ,  dysfunction ,  Autophagy ,  *presenilin ,  Amyloid ,  pathogenesis ,  *secretase ,  *gamma-secretase ,  Signal Transduction ,  glycoprotein ,  animal protein
Semi thesaurus term： cellular signal transduction , 【Automatic Indexing@JST】

Author keywords (7)： presenilin ,  γ-secretase ,  autophagy ,  Alzheimer disease ,  proteostasis ,  intramembrane proteolysis ,  membrane trafficking

JST classification (4)： Cell physiology in general  (EF02010S) ,  Congenital diseases,deformities in general.  (GD03010V) ,  Biological function  (EB03040U) ,  Function of cell components  (EF03060C)

Reference (163)：

• Sherrington, R.; Rogaev, E.I.; Liang, Y.; Rogaeva, E.A.; Levesque, G.; Ikeda, M.; Chi, H.; Lin, C.; Li, G.; Holman, K.; et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer’s disease. Nature 1995, 375, 754-760.
• Levy-Lahad, E.; Wasco, W.; Poorkaj, P.; Romano, D.M.; Oshima, J.; Pettingell, W.H.; Yu, C.E.; Jondro, P.D.; Schmidt, S.D.; Wang, K. Candidate gene for the chromosome 1 familial Alzheimer’s disease locus. Science 1995, 269, 973-977.
• Rogaev, E.I.; Sherrington, R.; Rogaeva, E.A.; Levesque, G.; Ikeda, M.; Liang, Y.; Chi, H.; Lin, C.; Holman, K.; Tsuda, T. Familial Alzheimer’s disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer’s disease type 3 gene. Nature 1995, 376, 775-778.
• Duggan, S.P.; McCarthy, J.V. Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways. Cell Signal. 2016, 28, 1-11.
• De Strooper, B.; Iwatsubo, T.; Wolfe, M.S. Presenilins and γ-secretase: Structure, function, and role in Alzheimer Disease. Cold Spring Harb. Perspect. Med. 2012, 2, a006304.

Terms in the title (3)： 膜蛋白質 ,  プレセニリン ,  γ-セクレターゼ