Art

J-GLOBAL ID：201902245182172009   Reference number：19A2242799

Continuous evolution of base editors with expanded target compatibility and improved activity

標的適合性が広く活性が高い塩基エディターの連続進化

Author (20)： THURONYI Benjamin W. (Merkin Inst. of Transformative Technol. in Healthcare, Broad Inst. of Harvard and MIT, Cambridge, MA, USA) ,  KOBLAN Luke W. (Merkin Inst. of Transformative Technol. in Healthcare, Broad Inst. of Harvard and MIT, Cambridge, MA, USA) ,  LEVY Jonathan M. (Merkin Inst. of Transformative Technol. in Healthcare, Broad Inst. of Harvard and MIT, Cambridge, MA, USA) ,  YEH Wei-Hsi (Merkin Inst. of Transformative Technol. in Healthcare, Broad Inst. of Harvard and MIT, Cambridge, MA, USA) ,  NEWBY Gregory A. (Merkin Inst. of Transformative Technol. in Healthcare, Broad Inst. of Harvard and MIT, Cambridge, MA, USA) ,  WILSON Christopher (Merkin Inst. of Transformative Technol. in Healthcare, Broad Inst. of Harvard and MIT, Cambridge, MA, USA) ,  LIU David R. (Merkin Inst. of Transformative Technol. in Healthcare, Broad Inst. of Harvard and MIT, Cambridge, MA, USA) ,  THURONYI Benjamin W. (Dep. of Chemistry and Chemical Biology, Harvard Univ., Cambridge, MA, USA) ,  KOBLAN Luke W. (Dep. of Chemistry and Chemical Biology, Harvard Univ., Cambridge, MA, USA) ,  LEVY Jonathan M. (Dep. of Chemistry and Chemical Biology, Harvard Univ., Cambridge, MA, USA) ,  YEH Wei-Hsi (Dep. of Chemistry and Chemical Biology, Harvard Univ., Cambridge, MA, USA) ,  ZHENG Christine (Dep. of Chemistry and Chemical Biology, Harvard Univ., Cambridge, MA, USA) ,  NEWBY Gregory A. (Dep. of Chemistry and Chemical Biology, Harvard Univ., Cambridge, MA, USA) ,  WILSON Christopher (Dep. of Chemistry and Chemical Biology, Harvard Univ., Cambridge, MA, USA) ,  LIU David R. (Dep. of Chemistry and Chemical Biology, Harvard Univ., Cambridge, MA, USA) ,  YEH Wei-Hsi (Program in Speech and Hearing Bioscience and Technol., Harvard Medical School, Boston, MA, USA) ,  BHAUMIK Mantu (Dep. of Neurology, F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School, Boston, MA, USA) ,  SHUBINA-OLEINIK Olga (Dep.s of Otolaryngology and Neurology, F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School, Boston, MA, USA) ,  HOLT Jeffrey R. (Dep.s of Otolaryngology and Neurology, F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School, Boston, MA, USA) ,  LIU David R. (Howard Hughes Medical Inst., Harvard Univ., Cambridge, MA, USA)
Material： Nature Biotechnology  (Nat Biotechnol)
Volume： 37  Issue： 9  Page： 1070-1079  Publication year： Sep. 2019 
JST Material Number： H0870A  ISSN： 1087-0156  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *editor ,  protein ,  editing ,  point mutation ,  wild type ,  DNA ,  *adaptability ,  catalyst ,  enzyme ,  nitrogen heterocyclic compound ,  urea compound
Semi thesaurus term： APOBEC1 ,  CRISPR配列 , 【Automatic Indexing@JST】

JST classification (1)： Gene manipulation  (EC02050B)

Substance index (1)： Cytosine

Terms in the title (5)： 標的 ,  適合性 ,  活性 ,  塩基エディター ,  進化