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J-GLOBAL ID：201902245365609585   Reference number：19A1648224

MicroRNA-155 Promotes Heat Stress-Induced Inflammation via Targeting Liver X Receptor α in Microglia

マイクロRNA-155はミクログリアにおいて肝臓X受容体αを標的とすることにより熱ストレス誘導炎症を促進する【JST・京大機械翻訳】

Author (11)： Li Ping (Laboratory of Extreme Environmental Medicine, Department of Tropical Medicine, Army Medical University, Chongqing, China) ,  Wang Gong (Laboratory of Extreme Environmental Medicine, Department of Tropical Medicine, Army Medical University, Chongqing, China) ,  Wang Gong (Department of Neurology, Xinqiao Hospital, Army Medical University, Chongqing, China) ,  Zhang Xiao-Liang (Laboratory of Extreme Environmental Medicine, Department of Tropical Medicine, Army Medical University, Chongqing, China) ,  Zhang Xiao-Liang (Department of Cardiology, Kunming General Hospital of Chengdu Military Command, Yunnan, China) ,  He Gen-Lin (Laboratory of Extreme Environmental Medicine, Department of Tropical Medicine, Army Medical University, Chongqing, China) ,  Luo Xue (Laboratory of Extreme Environmental Medicine, Department of Tropical Medicine, Army Medical University, Chongqing, China) ,  Yang Ju (Laboratory of Extreme Environmental Medicine, Department of Tropical Medicine, Army Medical University, Chongqing, China) ,  Luo Zhen (Laboratory of Extreme Environmental Medicine, Department of Tropical Medicine, Army Medical University, Chongqing, China) ,  Shen Ting-Ting (Laboratory of Extreme Environmental Medicine, Department of Tropical Medicine, Army Medical University, Chongqing, China) ,  Yang Xue-Sen (Laboratory of Extreme Environmental Medicine, Department of Tropical Medicine, Army Medical University, Chongqing, China)
Material： Frontiers in Cellular Neuroscience (Web)
Volume： 13  Page： 12  Publication year： 2019 
JST Material Number： U7064A  ISSN： 1662-5102  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Background: The neuroinflammat...

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Thesaurus term： *microglia ,  *heat stress ,  CD11b antigen ,  NF-kappaB ,  Western blotting ,  Up-Regulation ,  interleukin 1 ,  phosphorylation ,  targeting ,  TNF alpha ,  *Inflammation ,  Inflammation reaction ,  *MicroRNAs ,  immune response ,  bioassay
Semi thesaurus term： immunological reaction ,  p65 , 【Automatic Indexing@JST】

Author keywords (5)： heat stress ,  microRNA-155 ,  inflammation ,  LXRα ,  microglia

JST classification (2)： Basic neurology  (GN01020W) ,  Cell physiology in general  (EF02010S)

Reference (74)：

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• Biber K., Owens T., Boddeke H. (2014). What is microglia neurotoxicity (Not)? Glia 62 841-854. doi: 10.1002/glia.22654
• Biedenkapp J. C., Leon L. R. (2013). Increased cytokine and chemokine gene expression in the CNS of mice during heat stroke recovery. Am. J. Phys. Regul. Integr. Comp. Physiol. 305 R978-R986. doi: 10.1152/ajpregu.00011.2013
• Block M. L., Zecca L., Hong J. (2007). Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 8 57-69. doi: 10.1038/nrn2038
• Bouchama A K. J. (2002). Heat stroke. N. Engl. J. Med. 25 1978-1988. doi: 10.1056/NEJMra011089

Terms in the title (8)： マイクロRNA-155 ,  ミクログリア ,  肝臓X受容体α ,  標的 ,  熱ストレス ,  誘導 ,  炎症 ,  促進