Art

J-GLOBAL ID：201902247862385900   Reference number：19A2448099

Targeted Repair of p47-CGD in iPSCs by CRISPR/Cas9: Functional Correction without Cleavage in the Highly Homologous Pseudogenes

CRISPR/Cas9によるIPSCにおけるp47-CGDの標的修復:高度に相同な偽遺伝子における切断を伴わない機能的補正【JST・京大機械翻訳】

Author (21)： Klatt Denise (Institute of Experimental Hematology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ,  Klatt Denise (REBIRTH Cluster of Excellence, Hannover Medical School, 30625 Hannover, Germany) ,  Cheng Erica (Institute of Experimental Hematology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ,  Cheng Erica (REBIRTH Cluster of Excellence, Hannover Medical School, 30625 Hannover, Germany) ,  Philipp Friederike (Institute of Experimental Hematology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ,  Philipp Friederike (REBIRTH Cluster of Excellence, Hannover Medical School, 30625 Hannover, Germany) ,  Philipp Friederike (Fraunhofer Institute for Toxicology and Experimental Medicine, 30625 Hannover, Germany) ,  Selich Anton (Institute of Experimental Hematology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ,  Dahlke Julia (Institute of Experimental Hematology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ,  Dahlke Julia (REBIRTH Cluster of Excellence, Hannover Medical School, 30625 Hannover, Germany) ,  Schmidt Reinhold E. (Department of Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany) ,  Schott Juliane W. (Institute of Experimental Hematology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ,  Buening Hildegard (Institute of Experimental Hematology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ,  Buening Hildegard (REBIRTH Cluster of Excellence, Hannover Medical School, 30625 Hannover, Germany) ,  Hoffmann Dirk (Institute of Experimental Hematology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ,  Hoffmann Dirk (REBIRTH Cluster of Excellence, Hannover Medical School, 30625 Hannover, Germany) ,  Thrasher Adrian J. (Infection, Immunity and Inflammation Program, Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK) ,  Thrasher Adrian J. (Great Ormond Street Hospital NHS Foundation Trust, London WC1N 1EH, UK) ,  Schambach Axel (Institute of Experimental Hematology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ,  Schambach Axel (REBIRTH Cluster of Excellence, Hannover Medical School, 30625 Hannover, Germany) ,  Schambach Axel (Division of Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA)
Material： Stem Cell Reports
Volume： 13  Issue： 4  Page： 590-598  Publication year： 2019 
JST Material Number： W3132A  ISSN： 2213-6711  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Mutations in the NADPH oxidase...

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Thesaurus term： subunit ,  oxidase ,  induced pluripotent stem cell ,  bacterium ,  mutation ,  *gene ,  modeling ,  human(primates) ,  *pseudogene ,  targeting ,  complex(substance)
Semi thesaurus term： 特異性 ,  *p47 ,  *Cas9 ,  *CRISPR配列 , 【Automatic Indexing@JST】

Author keywords (8)： chronic granulomatous disease (CGD) ,  NADPH oxidase ,  p47phox ,  NCF1 ,  CRISPR/Cas9 ,  human induced pluripotent stem cells ,  gene editing ,  pseudogenes

JST classification (3)： Cell physiology in general  (EF02010S) ,  Cell and tissue culture methods  (EA03040R) ,  Gene manipulation  (EC02050B)

Terms in the title (8)： CRISPR ,  Cas9 ,  IPSC ,  p47 ,  CGD ,  標的 ,  修復 ,  偽遺伝子