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J-GLOBAL ID：201902248279651654   Reference number：19A1906201

Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring

ナフタレン環を持つ小分子化合物によるGTP結合H-Ras蛋白質のアロステリック阻害の分子基盤【JST・京大機械翻訳】

Author (9)： Matsumoto Shigeyuki (Division of Molecular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Japan) ,  Hiraga Toshiki (Division of Molecular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Japan) ,  Hayashi Yuki (Division of Molecular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Japan) ,  Yoshikawa Yoko (Division of Molecular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Japan) ,  Tsuda Chiemi (Division of Molecular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Japan) ,  Araki Mitsugu (Medicinal Frontier Department, KNC Laboratories Company, Ltd., Japan) ,  Neya Masahiro (Medicinal Frontier Department, KNC Laboratories Company, Ltd., Japan) ,  Shima Fumi (Division of Molecular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Japan) ,  Kataoka Tohru (Division of Molecular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Japan)
Material： Biochemistry
Volume： 57  Issue： 36  Page： 5350-5358  Publication year： 2018 
JST Material Number： B0270B  ISSN： 0006-2960  CODEN： BICHAW  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： The ras oncogene products (H-R...

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Thesaurus term： conformational transition ,  imide ,  interaction ,  complex(substance) ,  mutation ,  antitumor drug ,  NMR ,  switch ,  *Ras protein ,  hydrophobic ,  binding site ,  human(primates) ,  polyacene
Semi thesaurus term： 阻害剤 ,  *H-Ras , 【Automatic Indexing@JST】

JST classification (3)： Molecular structure  (EB03020Y) ,  Cell physiology in general  (EF02010S) ,  Biological function  (EB03040U)

Substance index (1)： Naphthalene

Terms in the title (8)： ナフタレン ,  環 ,  分子化合物 ,  GTP ,  H-Ras蛋白質 ,  アロステリック阻害 ,  分子 ,  基盤