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J-GLOBAL ID：201902248503804223   Reference number：19A0375528

Cytome micronucleus assays with a metabolically competent human derived liver cell line (Huh6): A promising approach for routine testing of chemicals?

代謝能のあるヒト由来肝細胞株(HUH6)による細胞小核アッセイ:化学物質のルーチン試験の有望なアプローチ?【JST・京大機械翻訳】

Author (6)： Misik Miroslav (Institute of Cancer Research, Department of Internal Medicine 1, Medical University of Vienna, Vienna, Austria) ,  Nersesyan Armen (Institute of Cancer Research, Department of Internal Medicine 1, Medical University of Vienna, Vienna, Austria) ,  Bolognesi Claudia (Environmental Carcinogenesis Unit, Ospedale Policlinico San Martino, Genoa, Italy) ,  Kundi Michael (Center for Public Health, Department of Environmental Health, Medical University of Vienna, Vienna, Austria) ,  Ferk Franziska (Institute of Cancer Research, Department of Internal Medicine 1, Medical University of Vienna, Vienna, Austria) ,  Knasmueller Siegfried (Institute of Cancer Research, Department of Internal Medicine 1, Medical University of Vienna, Vienna, Austria)
Material： Environmental and Molecular Mutagenesis  (Environ Mol Mutagen)
Volume： 60  Issue： 2  Page： 134-144  Publication year： 2019 
JST Material Number： W0213A  ISSN： 0893-6692  CODEN： EMMUEG  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： One of the main problems of in...

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Thesaurus term： serum concentration ,  DNA lesion ,  serum ,  characterization ,  cisplatin ,  in vitro experiment ,  *hepatocyte ,  reproducibility ,  *chemical substance ,  *metabolism ,  sensitivity ,  genetic toxicity ,  *micronucleus ,  *human(primates) ,  alicyclic compound ,  lactone ,  phenolic compound ,  glycoside(except carbohydrate) ,  olefin compound ,  pyranoside ,  glucoside ,  phenol ether ,  polynuclear aromatic compound

Author keywords (4)： Huh6 ,  micronuclei ,  nucleoplasmatic bridges ,  serum

JST classification (3)： Bioassay  (EA03060N) ,  Molecular genetics in general  (EC02010J) ,  Genetic variation  (EC01030Y)

Substance index (1)： Etoposide

Terms in the title (9)： 代謝 ,  ヒト ,  細胞株 ,  細胞 ,  小核 ,  アッセイ ,  化学物質 ,  ルーチン ,  試験