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J-GLOBAL ID：201902250389554137   Reference number：19A0176941

¹⁸F-Labeled Pyrido[3,4-d]pyrimidine as an Effective Probe for Imaging of L858R Mutant Epidermal Growth Factor Receptor

L858R変異体表皮成長因子受容体のイメージングのための効果的プローブとしての18F標識ピリド[3,4-d]ピリミジン【JST・京大機械翻訳】

Author (14)： Kimura Hiroyuki (Graduate School of Pharmaceutical Sciences, Kyoto University, Japan) ,  Kimura Hiroyuki (Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Japan) ,  Okuda Haruka (Graduate School of Pharmaceutical Sciences, Kyoto University, Japan) ,  Ishiguro Masumi (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University, Japan) ,  Arimitsu Kenji (Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Japan) ,  Arimitsu Kenji (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University, Japan) ,  Makino Akira (Biomedical Imaging Research Center (BIRC), University of Fukui, Japan) ,  Nishii Ryuichi (National Institute of Radiological Sciences, Japan) ,  Miyazaki Anna (Graduate School of Pharmaceutical Sciences, Kyoto University, Japan) ,  Yagi Yusuke (Graduate School of Pharmaceutical Sciences, Kyoto University, Japan) ,  Watanabe Hiroyuki (Graduate School of Pharmaceutical Sciences, Kyoto University, Japan) ,  Kawasaki Ikuo (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University, Japan) ,  Ono Masahiro (Graduate School of Pharmaceutical Sciences, Kyoto University, Japan) ,  Saji Hideo (Graduate School of Pharmaceutical Sciences, Kyoto University, Japan)
Material： ACS Medicinal Chemistry Letters
Volume： 8  Issue： 4  Page： 418-422  Publication year： 2017 
JST Material Number： W5043A  ISSN： 1948-5875  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： In nonsmall-cell lung carcinom...

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Thesaurus term： *probe ,  Mutation ,  *image processing ,  fluorination ,  tumor ,  molecular target therapy ,  *EGF receptor ,  receptor tyrosine kinase ,  non-small cell lung cancer ,  visualization ,  biodistribution ,  Drug Resistance ,  PET (tomography) ,  cancer bearing mouse ,  *Genetic Variation
Semi thesaurus term： *variation(biology) , 【Automatic Indexing@JST】

Author keywords (5)： Epidermal growth factor receptor tyrosine kinase (EGFR-TK) ,  L858R mutant EGFR ,  positron emission tomography ,  fluorin-18 ,  4-(anilino)pyrido[3 4-d]pyrimidine

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Physicochemical pharmacy in general  (GV01010J)

Terms in the title (6)： 変異体 ,  表皮成長因子受容体 ,  イメージング ,  プローブ ,  標識 ,  ピリミジン