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J-GLOBAL ID：201902250630008135   Reference number：19A0714922

Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines

新規小分子SIRT2阻害剤は白血病細胞株における細胞死を誘導する【JST・京大機械翻訳】

Author (8)： Kozako Tomohiro (Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan) ,  Mellini Paolo (Faculty of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan) ,  Ohsugi Takeo (Department of Hematology and Immunology, Rakuno Gakuen University, Hokkaido, Japan) ,  Aikawa Akiyoshi (Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan) ,  Uchida Yu-ichiro (Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan) ,  Honda Shin-ichiro (Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan) ,  Suzuki Takayoshi (Faculty of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan) ,  Suzuki Takayoshi (CREST, Japan Science and Technology Agency (JST), Saitama, Japan)
Material： BMC Cancer (Web)
Volume： 18  Issue： 1  Page： 791  Publication year： 2018 
JST Material Number： U7305A  ISSN： 1471-2407  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Sirtuin 2 (SIRT2) is a member ...

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Thesaurus term： human ,  siRNA ,  caspase ,  Down-Regulation ,  *small molecule ,  flow cytometry ,  T cell ,  therapy ,  Apoptosis ,  lymphoma ,  Autophagy ,  HeLa cell ,  Cell Proliferation ,  Sirtuins ,  *leukemia cell
Semi thesaurus term： *阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： Human T-cell leukemia virus-1 ,  Adult T-cell leukemia/lymphoma ,  SIRT2 ,  Apoptosis ,  Caspase-independent cell death

JST classification (3)： Cell physiology in general  (EF02010S) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Reference (49)：

• Trends Pharmacol Sci; Emerging role of Sirtuin 2 in the regulation of mammalian metabolism; P Gomes, TF Outeiro, C Cavadas; 36; 11; 2015; 756-768; 10.1016/j.tips.2015.08.001; citation_id=CR1
• Proc Natl Acad Sci U S A; The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases; J Landry, A Sutton, ST Tafrov, RC Heller, J Stebbins, L Pillus, R Sternglanz; 97; 11; 2000; 5807-5811; 10.1073/pnas.110148297; citation_id=CR2
• Cell; An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing; JC Tanny, GJ Dowd, J Huang, H Hilz, D Moazed; 99; 7; 1999; 735-745; 10.1016/S0092-8674(00)81671-2; citation_id=CR3
• Cancer Cell; SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity; HS Kim, A Vassilopoulos, RH Wang, T Lahusen, Z Xiao, X Xu, C Li, TD Veenstra, B Li, H Yu; 20; 4; 2011; 487-499; 10.1016/j.ccr.2011.09.004; citation_id=CR4
• Genes Cells; Role of NAD-dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin-induced cell death in vertebrate cells; N Matsushita, Y Takami, M Kimura, S Tachiiri, M Ishiai, T Nakayama, M Takata; 10; 4; 2005; 321-332; 10.1111/j.1365-2443.2005.00836.x; citation_id=CR5

Terms in the title (7)： 小分子 ,  SIRT2 ,  阻害剤 ,  白血病 ,  細胞株 ,  細胞死 ,  誘導