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J-GLOBAL ID：201902251404847996   Reference number：19A0874943

Disulfiram enhanced delivery of orally administered copper into the central nervous system in Menkes disease mouse model

Menkes病マウスモデルにおける中枢神経系への経口投与銅のジスルフィラム増強デリバリー【JST・京大機械翻訳】

Author (8)： Hoshina Takao (Department of Pediatrics, Osaka City University Graduate School of Medicine, Osaka, Japan) ,  Nozaki Satoshi (Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research and Center for Life Science Technologies, Kobe, Hyogo, Japan) ,  Hamazaki Takashi (Department of Pediatrics, Osaka City University Graduate School of Medicine, Osaka, Japan) ,  Kudo Satoshi (Department of Pediatrics, Osaka City University Graduate School of Medicine, Osaka, Japan) ,  Nakatani Yuka (Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research and Center for Life Science Technologies, Kobe, Hyogo, Japan) ,  Kodama Hiroko (Department of Pediatrics, Teikyo University School of Medicine, Tokyo, Japan) ,  Shintaku Haruo (Department of Pediatrics, Osaka City University Graduate School of Medicine, Osaka, Japan) ,  Watanabe Yasuyoshi (Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research and Center for Life Science Technologies, Kobe, Hyogo, Japan)
Material： Journal of Inherited Metabolic Disease
Volume： 41  Issue： 6  Page： 1285-1291  Publication year： 2018 
JST Material Number： T0139A  ISSN： 0141-8955  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Menkes disease (MD) is an X-li...

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Thesaurus term： human(primates) ,  *copper ,  *oral administration ,  autoradiography ,  *mouse(animal) ,  recessive ,  pretreatment ,  blood-brain barrier ,  dysfunction ,  cerebral cortex ,  wild type ,  enzyme inhibitor ,  organosulphur compound
Semi thesaurus term： ex vivo実験 ,  器官 ,  モデルマウス ,  神経変性 ,  *マウスモデル , 【Automatic Indexing@JST】

JST classification (2)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Basic neurology  (GN01020W)

Substance index (1)： Disulfiram

Terms in the title (8)： Menkes病 ,  マウスモデル ,  中枢神経系 ,  経口投与 ,  銅 ,  ジスルフィラム ,  増強 ,  デリバリー