Art

J-GLOBAL ID：201902252015717915   Reference number：19A2931724

Brain Activation in a Cynomolgus Macaque Model of Chymopapain-Induced Discogenic Low Back Pain: A Preliminary Study

キモパパイン誘発性椎間板性腰痛のカニクイザルモデルにおける脳活性化:予備的研究

Author (16)： Ushirozako Hiroki (Department of Orthopedic Surgery, Hamamatsu University School of Medicine) ,  Yoshida Go (Department of Orthopedic Surgery, Hamamatsu University School of Medicine) ,  Togawa Daisuke (Department of Orthopedic Surgery and Division of Geriatric Musculoskeletal Health, Hamamatsu University School of Medicine) ,  Omura Takao (Department of Orthopedic Surgery, Hamamatsu University School of Medicine) ,  Hasegawa Tomohiko (Department of Orthopedic Surgery, Hamamatsu University School of Medicine) ,  Yamato Yu (Department of Orthopedic Surgery, Hamamatsu University School of Medicine) ,  Banno Tomohiro (Department of Orthopedic Surgery, Hamamatsu University School of Medicine) ,  Arima Hideyuki (Department of Orthopedic Surgery, Hamamatsu University School of Medicine) ,  Oe Shin (Department of Orthopedic Surgery and Division of Geriatric Musculoskeletal Health, Hamamatsu University School of Medicine) ,  Mihara Yuki (Department of Orthopedic Surgery, Hamamatsu University School of Medicine) ,  Yamada Tomohiro (Department of Orthopedic Surgery, Hamamatsu University School of Medicine) ,  Natsume Takahiro (Pharmacology Group, Hamamatsu Pharma Research, Inc.) ,  Ogawa Shinya (Pharmacology Group, Hamamatsu Pharma Research, Inc.) ,  Awaga Yuji (Pharmacology Group, Hamamatsu Pharma Research, Inc.) ,  Takamatsu Hiroyuki (Pharmacology Group, Hamamatsu Pharma Research, Inc.) ,  Matsuyama Yukihiro (Department of Orthopedic Surgery, Hamamatsu University School of Medicine)
Material： Spine Surgery and Related Research (Web)
Volume： 3  Issue： 4  Page： 368-376(J-STAGE)  Publication year： 2019 
JST Material Number： U1327A  ISSN： 2432-261X  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Macaca fascicularis ,...
Semi thesaurus term： odynometer ,...

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Author keywords (8)： chymopapain ,  discogenic low back pain ,  nonhuman primate ,  pressure test ,  brain activation ,  functional magnetic resonance imaging ,  secondary somatosensory cortex ,  insular cortex

JST classification (2)： Basic medicine on musculoskeletal system  (GG01020B) ,  Laboratry organisms  (EA03070Y)

Reference (30)：

• 1. Takahashi N, Kikuchi S, Konno S, et al. Discrepancy between disability and the severity of low back pain: demographic, psychologic, and employment-related factors. Spine (Phila Pa 1976). 2006;31 (8):931-9; discussion 40.
• 2. Ohtori S, Inoue G, Miyagi M, et al. Pathomechanisms of discogenic low back pain in humans and animal models. Spine J. 2015;15 (6):1347-55.
• 3. deCharms RC, Maeda F, Glover GH, et al. Control over brain activation and pain learned by using real-time functional MRI. Proc Natl Acad Sci U S A. 2005;102 (51):18626-31.
• 4. Giesecke T, Gracely RH, Grant MA, et al. Evidence of augmented central pain processing in idiopathic chronic low back pain. Arthritis Rheum. 2004;50 (2):613-23.
• 5. Apkarian AV, Sosa Y, Sonty S, et al. Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. J Neurosci. 2004;24 (46):10410-5.

Terms in the title (6)： キモパパイン ,  椎間板性腰痛 ,  カニクイザル ,  モデル ,  脳活性化 ,  予備的研究