Art

J-GLOBAL ID：201902252096583122   Reference number：19A2046889

Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages

メタボリックシンドロームに対する性ホルモン結合グロブリンの保護効果:脂肪細胞およびマクロファージに対する抗炎症および脂肪分解効果を示すin vitro証拠【JST・京大機械翻訳】

Author (10)： Yamazaki Hiroki (Department of Rheumatology and Allergy, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Kushiyama Akifumi (Division of Diabetes and Metabolism, Institute for Adult Diseases, Asahi Life Foundation, 2-2-6, Bakuro-cho, Chuo-ku, Tokyo 103-0002, Japan) ,  Sakoda Hideyuki (Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake-cho, Miyazaki, Miyazaki 889-1692, Japan) ,  Fujishiro Midori (Division of Diabetes and Metabolic Diseases, Nihon University School of Medicine, 30-1, Oyaguchi Kami-cho, Itabashi-ku, Tokyo 173-8610, Japan) ,  Yamamotoya Takeshi (Department of Medical Science, Graduate School of Medicine, University of Hiroshima, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima 734-8551, Japan) ,  Nakatsu Yusuke (Department of Medical Science, Graduate School of Medicine, University of Hiroshima, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima 734-8551, Japan) ,  Kikuchi Takako (Division of Diabetes and Metabolism, Institute for Adult Diseases, Asahi Life Foundation, 2-2-6, Bakuro-cho, Chuo-ku, Tokyo 103-0002, Japan) ,  Kaneko Sunao (Department of Diabetes and Metabolic Diseases, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan) ,  Tanaka Hirotoshi (Department of Rheumatology and Allergy, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Asano Tomoichiro (Department of Medical Science, Graduate School of Medicine, University of Hiroshima, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima 734-8551, Japan)
Material： Mediators of Inflammation (Web)
Volume： 2018  Page： Null  Publication year： 2018 
JST Material Number： U7804A  ISSN： 0962-9351  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Sex hormone-binding globulin (...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=19A2046889&from=J-GLOBAL&jstjournalNo=U7804A") }}

Thesaurus term： coculture ,  *macrophage ,  lipopolysaccharide ,  *Inflammation ,  gene ,  interleukin 6 ,  *anti-inflammatory action ,  *protective action ,  *fat cell ,  Diabetes Mellitus ,  *in vitro experiment ,  *metabolic syndrome ,  serum concentration ,  steroid ,  estrogen ,  steroid hormone ,  phenolic compound ,  diol ,  enone ,  alicyclic alcohol ,  alicyclic ketone

JST classification (1)： Metabolic diseases,nutritional diseases in general.  (GD05010J)

Substance index (2)： Estradiol ,  Testosterone

Reference (59)：

• G. V. Avvakumov, A. Cherkasov, Y. A. Muller, G. L. Hammond, "Structural analyses of sex hormone-binding globulin reveal novel ligands and function," Molecular and Cellular Endocrinology, vol. 316, no. 1, pp. 13-23, 2010.
• Z. Sumer-Bayraktar, T. Nguyen-Khuong, R. Jayo, D. D. Y. Chen, S. Ali, N. H. Packer, M. Thaysen-Andersen, "Micro- and macroheterogeneity of N-glycosylation yields size and charge isoforms of human sex hormone binding globulin circulating in serum," Proteomics, vol. 12, no. 22, pp. 3315-3327, 2012.
• G. L. Hammond, "Diverse roles for sex hormone-binding globulin in reproduction," Biology of Reproduction, vol. 85, no. 3, pp. 431-441, 2011.
• C. H. Liao, H. Y. Li, H. J. Yu, H. S. Chiang, M. S. Lin, C. H. Hua, W. Y. Ma, "Low serum sex hormone-binding globulin: marker of inflammation?," Clinica Chimica Acta, vol. 413, no. 7-8, pp. 803-807, 2012.
• M. Maggio, G. P. Ceda, F. Lauretani, S. Bandinelli, A. M. Corsi, F. Giallauria, J. M. Guralnik, G. Zuliani, C. Cattabiani, S. Parrino, F. Ablondi, E. Dall'Aglio, G. Ceresini, S. Basaria, L. Ferrucci, "SHBG, sex hormones, and inflammatory markers in older women," The Journal of Clinical Endocrinology & Metabolism, vol. 96, no. 4, pp. 1053-1059, 2011.

Terms in the title (8)： メタボリックシンドローム ,  性ホルモン結合グロブリン ,  保護効果 ,  脂肪細胞 ,  マクロファージ ,  炎症 ,  脂肪分解 ,  証拠