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J-GLOBAL ID：201902252379392687   Reference number：19A1344507

TUBB1 dysfunction in inherited thrombocytopenia causes genome instability

遺伝性血小板減少症のTUBB1機能不全はゲノム不安定性を引き起こす【JST・京大機械翻訳】

Author (17)： Matsumura Takayoshi (Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore) ,  Nakamura-Ishizu Ayako (Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore) ,  Nakamura-Ishizu Ayako (International Research Centre for Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Takaoka Kensuke (Department of Haematology and Oncology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan) ,  Maki Hiroaki (Department of Haematology and Oncology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan) ,  Muddineni Siva S. N. A. (Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore) ,  Wang Chelsia Q. (Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore) ,  Suzushima Hitoshi (Kumamoto Shinto General Hospital, Kumamoto, Japan) ,  Kawakita Makoto (Kumamoto Dai-Ichi Hospital, Kumamoto, Japan) ,  Asou Norio (International Medical Centre, Saitama Medical University, Saitama, Japan) ,  Matsuoka Masao (Department of Haematology, Rheumatology, and Infectious Diseases, Kumamoto University School of Medicine, Kumamoto, Japan) ,  Kurokawa Mineo (Department of Haematology and Oncology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan) ,  Osato Motomi (Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore) ,  Osato Motomi (International Research Centre for Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Osato Motomi (Centre for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto, Japan) ,  Suda Toshio (Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore) ,  Suda Toshio (International Research Centre for Medical Sciences, Kumamoto University, Kumamoto, Japan)
Material： British Journal of Haematology  (Br J Haematol)
Volume： 185  Issue： 5  Page： 888-902  Publication year： 2019 
JST Material Number： C0969B  ISSN： 0007-1048  CODEN： BJHEAL  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Inherited thrombocytopenia is ...

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Thesaurus term： gene ,  apoptosis ,  *heredity ,  *dysfunction ,  in vitro experiment ,  DNA lesion ,  *thrombocytopenia ,  microtubule ,  bone marrow ,  p53 protein
Semi thesaurus term： 遺伝子ノックダウン法 ,  TP53 ,  悪性腫瘍 ,  悪性度 ,  *ゲノム不安定性 , 【Automatic Indexing@JST】

Author keywords (5)： inherited thrombocytopenia ,  TUBB1 ,  microtubules ,  apoptosis ,  genome instability

JST classification (2)： Hematologic diseases  (GK03000F) ,  Genetic variation  (EC01030Y)

Terms in the title (3)： 遺伝性血小板減少症 ,  機能不全 ,  ゲノム不安定性