Art

J-GLOBAL ID：201902252683822029   Reference number：19A2444797

Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis

ファージ尾部繊維変異誘発によるファージ宿主域のエンジニアリングと細菌耐性の抑制【JST・京大機械翻訳】

Author (20)： Yehl Kevin (Synthetic Biology Group, MIT Synthetic Biology Center, The Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA) ,  Yehl Kevin (Research Laboratory of Electronics, MIT, Cambridge, MA 02139, USA) ,  Lemire Sebastien (Synthetic Biology Group, MIT Synthetic Biology Center, The Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA) ,  Lemire Sebastien (Research Laboratory of Electronics, MIT, Cambridge, MA 02139, USA) ,  Yang Andrew C. (Synthetic Biology Group, MIT Synthetic Biology Center, The Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA) ,  Yang Andrew C. (Department of Bioengineering, Stanford University, Stanford, CA 94305, USA) ,  Ando Hiroki (Synthetic Biology Group, MIT Synthetic Biology Center, The Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA) ,  Ando Hiroki (Research Laboratory of Electronics, MIT, Cambridge, MA 02139, USA) ,  Mimee Mark (Synthetic Biology Group, MIT Synthetic Biology Center, The Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA) ,  Mimee Mark (Research Laboratory of Electronics, MIT, Cambridge, MA 02139, USA) ,  Torres Marcelo Der Torossian (Synthetic Biology Group, MIT Synthetic Biology Center, The Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA) ,  Torres Marcelo Der Torossian (Research Laboratory of Electronics, MIT, Cambridge, MA 02139, USA) ,  de la Fuente-Nunez Cesar (Synthetic Biology Group, MIT Synthetic Biology Center, The Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA) ,  de la Fuente-Nunez Cesar (Research Laboratory of Electronics, MIT, Cambridge, MA 02139, USA) ,  Lu Timothy K. (Synthetic Biology Group, MIT Synthetic Biology Center, The Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA) ,  Lu Timothy K. (Research Laboratory of Electronics, MIT, Cambridge, MA 02139, USA) ,  Lu Timothy K. (Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA) ,  Lu Timothy K. (Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA) ,  Lu Timothy K. (Department of Biological Engineering, MIT, Cambridge, MA 02129, USA) ,  Lu Timothy K. (Broad Institute of MIT and Harvard, Cambridge, MA, USA)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 179  Issue： 2  Page： 459-469.e9  Publication year： 2019 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： The rapid emergence of antibio...

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Thesaurus term： Heredity ,  human ,  high speed ,  *Bacteriophages ,  site-directed mutagenesis ,  *mutagenesis ,  antibody ,  antibacterial drug ,  in vitro experiment ,  *host range ,  *Bacteria ,  therapy ,  Proteins ,  Drug Resistance, Microbial ,  Enterobacteria phage T3 ,  *microorganism
Semi thesaurus term： ハイスループット ,  T3ファージ , 【Automatic Indexing@JST】

Author keywords (10)： bacteriophage ,  phage ,  virus ,  antimicrobial ,  synthetic biology ,  resistance ,  host-range ,  evolution ,  tail fiber ,  antibody

JST classification (1)： Cell physiology in general  (EF02010S)

Terms in the title (6)： ファージ ,  変異誘発 ,  宿主域 ,  エンジニアリング ,  細菌 ,  耐性