Art

J-GLOBAL ID：201902253140970716   Reference number：19A0994375

Candidate plasticity gene 16 mediates suppression of insulin gene expression in rat insulinoma INS-1 cells under glucotoxic conditions

候補可塑性遺伝子16は,糖毒性条件下のラットインスリノーマINS-1細胞におけるインスリン遺伝子発現の抑制を仲介する【JST・京大機械翻訳】

Author (10)： Nakane Tatsuto (Department of Life Sciences, Faculty of Agriculture, Kagawa University, Kagawa, 761-0795, Japan) ,  Ido Ayae (Department of Life Sciences, Faculty of Agriculture, Kagawa University, Kagawa, 761-0795, Japan) ,  Higuchi Takuma (Laboratory of Molecular Biology, Science Research Center, Kochi Medical School, Kochi, 783-8505, Japan) ,  Todaka Hiroshi (Department of Cardiovascular Control, Kochi Medical School, Kochi, 783-8505, Japan) ,  Morisawa Keiko (Laboratory of Molecular Biology, Science Research Center, Kochi Medical School, Kochi, 783-8505, Japan) ,  Nagamine Tadashi (Research Division, ROM Co., Ltd., Sapporo, 060-0062, Japan) ,  Fukunaga Kensaku (Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Kagawa, 761-0793, Japan) ,  Sakamoto Shuji (Laboratory of Molecular Biology, Science Research Center, Kochi Medical School, Kochi, 783-8505, Japan) ,  Murao Koji (Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Kagawa, 761-0793, Japan) ,  Sugiyama Yasunori (Department of Life Sciences, Faculty of Agriculture, Kagawa University, Kagawa, 761-0795, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 512  Issue： 2  Page： 189-195  Publication year： 2019 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Chronic hyperglycemia causes p...

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Thesaurus term： Transfection ,  Down-Regulation ,  Death ,  *gene ,  *insulin ,  protein kinase ,  Real Time Polymerase Chain Reaction ,  hyperglycemia ,  culture (biology) ,  Up-Regulation ,  Diabetes Mellitus ,  *gene expression ,  kinase ,  molecular mechanism ,  *hypoglycemic drug ,  *metabolic drug ,  *carbohydrate metabolic drug ,  *drug ,  *molecular genetic phenomenon ,  hexose ,  aldose

Author keywords (5)： CPG16 ,  Dclk1 ,  Glucotoxicity ,  Insulin ,  Diabetes

JST classification (3)： Pancreatic hormones  (EB08020H) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Pancreas  (EJ06050Y)

Substance index (1)： Glucose

Terms in the title (9)： 可塑性 ,  遺伝子 ,  糖毒性 ,  ラット ,  インスリノーマ ,  INS-1細胞 ,  インスリン ,  遺伝子発現 ,  仲介