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J-GLOBAL ID：201902253769732249   Reference number：19A2301623

Cluster of Differentiation 46 Is the Major Receptor in Human Blood-Brain Barrier Endothelial Cells for Uptake of Exosomes Derived from Brain-Metastatic Melanoma Cells (SK-Mel-28)

分化46のクラスターは脳転移メラノーマ細胞(SK-MEL-28)由来エキソソームの取り込みのためのヒト血液脳関門内皮細胞におけるMajor受容体である【JST・京大機械翻訳】

Author (9)： Kuroda Hiroki (Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan) ,  Tachikawa Masanori (Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan) ,  Yagi Yuta (Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan) ,  Umetsu Mina (Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan) ,  Nurdin Armania (Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan) ,  Miyauchi Eisuke (Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan) ,  Watanabe Michitoshi (Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan) ,  Uchida Yasuo (Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan) ,  Terasaki Tetsuya (Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan)
Material： Molecular Pharmaceutics
Volume： 16  Issue： 1  Page： 292-304  Publication year： 2019 
JST Material Number： W3686A  ISSN： 1543-8384  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Brain metastasis is a frequent...

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Thesaurus term： internalization ,  siRNA ,  Adenoviridae ,  *endothelial cell ,  *human ,  *Blood-Brain Barrier ,  peptide ,  integrin ,  proteomics ,  tumor cell ,  complication ,  Antigens, CD46 ,  Integrin alpha5 ,  *Exosomes ,  *brain metastasis ,  microorganism ,  animal virus ,  *Cardiovascular System

Author keywords (7)： exosomes ,  human blood-brain barrier ,  cross-linking ,  comprehensive proteomics SWATH ,  brain-metastatic cancer ,  virus receptor ,  CD46

JST classification (1)： Basic biopharmacy  (GY01021U)

Terms in the title (10)： 分化 ,  クラスター ,  脳転移 ,  メラノーマ細胞 ,  エキソソーム ,  取り込み ,  ヒト ,  血液脳関門 ,  内皮細胞 ,  受容体