Art

J-GLOBAL ID：201902254170750932   Reference number：19A1648619

Regulatory Role of GRK2 in the TLR Signaling-Mediated iNOS Induction Pathway in Microglial Cells

ミクログリア細胞におけるTLRシグナル伝達仲介iNOS誘導経路におけるGRK2の調節的役割【JST・京大機械翻訳】

Author (9)： Palikhe Sailesh (Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan) ,  Ohashi Wakana (Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan) ,  Sakamoto Takuya (Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan) ,  Hattori Kohshi (Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo, Japan) ,  Kawakami Masaaki (Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan) ,  Andoh Tsugunobu (Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan) ,  Yamazaki Hiromi (Faculty of Nursing Science, Tsuruga Nursing University, Tsuruga, Japan) ,  Hattori Yuichi (Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan) ,  Hattori Yuichi (The Research Institute of Cancer Prevention, Health Sciences University of Hokkaido, Tobetsu, Japan)
Material： Frontiers in Pharmacology (Web)
Volume： 10  Page： 59  Publication year： 2019 
JST Material Number： U7091A  ISSN： 1663-9812  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： G protein-coupled receptor kin...

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Thesaurus term： *microglia ,  internalization ,  STAT transcription factor ,  Inflammation ,  nitric oxide synthase ,  lipopolysaccharide ,  siRNA ,  Up-Regulation ,  Transfection ,  interferon beta ,  phosphorylation ,  protein expression ,  Toll-Like Receptor 4 ,  *G-Protein-Coupled Receptor Kinase 2 ,  *Nitric Oxide Synthase Type II

Author keywords (7)： GRK2 ,  iNOS ,  TLR signaling ,  interferon-β ,  IRF1 ,  STAT pathway ,  microglia

JST classification (2)： Basic research of anti-inflammatory drugs  (GW15010T) ,  Basic research of pharmacology of crude drugs  (GX06020J)

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Terms in the title (9)： ミクログリア細胞 ,  TLRシグナル ,  仲介 ,  iNOS ,  誘導 ,  経路 ,  GRK2 ,  調節 ,  役割