Art

J-GLOBAL ID：201902254779056988   Reference number：19A1706748

In Vitro Assessment of Supersaturation/Precipitation and Biological Membrane Permeation of Poorly Water-Soluble Drugs: A Case Study With Albendazole and Ketoconazole

難水溶性薬物の過飽和/沈殿と生体膜透過のin vitro評価:アルベンダゾールとケトコナゾールによる事例研究【JST・京大機械翻訳】

Author (8)： Kataoka Makoto (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan) ,  Takeyama Shoko (Pharmaceutical & ADMET Research Department, Daiichi Sankyo RD Novare Co., Ltd, 1-16-3 Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan) ,  Minami Keiko (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan) ,  Higashino Haruki (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan) ,  Kakimi Kohichi (Pharmaceutical & ADMET Research Department, Daiichi Sankyo RD Novare Co., Ltd, 1-16-3 Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan) ,  Fujii Yoshimine (Pharmaceutical & ADMET Research Department, Daiichi Sankyo RD Novare Co., Ltd, 1-16-3 Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan) ,  Takahashi Masayuki (Pharmaceutical & ADMET Research Department, Daiichi Sankyo RD Novare Co., Ltd, 1-16-3 Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan) ,  Yamashita Shinji (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan)
Material： Journal of Pharmaceutical Sciences  (J Pharm Sci)
Volume： 108  Issue： 8  Page： 2580-2587  Publication year： 2019 
JST Material Number： C0260B  ISSN： 0022-3549  CODEN： JPMSAE  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： This study aimed to elucidate ...

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Thesaurus term： *supersaturation ,  *precipitation (sedimentation) ,  powder ,  *membrane permeability ,  pharmaceutical preparation ,  dilution ,  *case study ,  dissolution ,  *in vitro experiment ,  *biomembrane ,  inventory quantity ,  solubility (ratio) ,  fatty acid ,  nitrogen heterocyclic compound ,  oxygen heterocyclic compound ,  aromatic chlorine compound ,  carboxamide ,  phenol ether ,  sulfide (organic) ,  carbamate ,  polynuclear aromatic compound
Semi thesaurus term： *難溶性薬物 , 【Automatic Indexing@JST】

Author keywords (5)： dissolution ,  phase separation ,  poorly water-soluble drug ,  precipitation ,  supersaturation

JST classification (1)： Basic biopharmacy  (GY01021U)

Substance index (2)： Ketoconazole ,  Albendazole

Terms in the title (9)： 難水溶性薬物 ,  過飽和 ,  沈殿 ,  生体 ,  膜透過 ,  評価 ,  アルベンダゾール ,  ケトコナゾール ,  研究