Art

J-GLOBAL ID：201902254920434925   Reference number：19A0138878

Anti-KL-6/MUC1 monoclonal antibody reverses resistance to trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity by capping MUC1

抗KL-6/MUC1モノクローナル抗体はMUC1をキャッピングすることによりトラスツズマブ仲介抗体依存性細胞媒介細胞毒性に対する抵抗性を逆転させる【JST・京大機械翻訳】

Author (13)： Namba Masashi (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan) ,  Hattori Noboru (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan) ,  Hamada Hironobu (Department of Physical Analysis and Therapeutic Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan) ,  Yamaguchi Kakuhiro (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan) ,  Okamoto Yohei (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan) ,  Nakashima Taku (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan) ,  Masuda Takeshi (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan) ,  Sakamoto Shinjiro (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan) ,  Horimasu Yasushi (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan) ,  Miyamoto Shintaro (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan) ,  Iwamoto Hiroshi (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan) ,  Fujitaka Kazunori (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan) ,  Kohno Nobuoki (Hiroshima Cosmopolitan University, 5-13-18 Ujinanishi, Minami-ku, Hiroshima, 734-0014, Japan)
Material： Cancer Letters  (Cancer Lett)
Volume： 442  Page： 31-39  Publication year： 2019 
JST Material Number： E0606B  ISSN： 0304-3835  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Polymorphic epithelial mucin (...

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Thesaurus term： mucin ,  sensitivity ,  drug therapy ,  breast tumor ,  tumor cell ,  siRNA ,  *cytotoxicity ,  Adenocarcinoma ,  *monoclonal antibody ,  epithelium ,  cell surface ,  breast cancer cell ,  overexpression ,  *Mucin-1 ,  membrane and film ,  histomembrane
Semi thesaurus term： *トラスツズマブ , 【Automatic Indexing@JST】

Author keywords (5)： MUC1 ,  KL-6 ,  Trastuzumab ,  Antibody-dependent cell-mediated cytotoxicity ,  Capping

JST classification (2)： Basic research of immunotherapeutic agents and blood preparations  (GW22010D) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Terms in the title (11)： KL-6 ,  MUC1 ,  モノクローナル抗体 ,  キャッピング ,  トラスツズマブ ,  仲介 ,  抗体 ,  性細胞 ,  細胞毒性 ,  抵抗性 ,  逆転