Art

J-GLOBAL ID：201902255347164196   Reference number：19A0421593

Anti-cell growth and anti-cancer stem cell activity of the hedgehog inhibitor GANT61 in poorly and undifferentiated thyroid cancer cells

甲状腺低分化・未分化癌細胞に対するヘッジホッグ阻害薬GANT61の抗腫瘍効果と癌幹細胞制御作用

Author (7)： SAITO WATARU (川崎医大 乳腺甲状腺外科学) ,  KUREBAYASHI JUN'ICHI (川崎医大 乳腺甲状腺外科学) ,  TANAKA KATSUHIRO (川崎医大 乳腺甲状腺外科学) ,  OTA YUSUKE (川崎医大 乳腺甲状腺外科学) ,  KOIKE YOSHIKAZU (川崎医大 乳腺甲状腺外科学) ,  KISHINO EIMI (川崎医大 乳腺甲状腺外科学) ,  KANOMATA NAOKI (川崎医大 病理学)
Material： 川崎医学会誌
Volume： 44  Issue： 2  Page： 95-106  Publication year： 2018 
JST Material Number： Z0386B  ISSN： 0386-5924  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： tumor cell ,...
Semi thesaurus term： *Thyroid poorly differentiated carcinoma ,...

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JST classification (3)： Experimental treatment for tumors  (GE02040Y) ,  Tumors(=neoplasms)of endocrine system  (GL04000P) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (2)： GANT-61 ,  Paclitaxel

Reference (20)：

• Brose MS, Nutting CM, Jarzab B, et al.: Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomized, double-blind, phase 3 trial. Lancet 384: 319-328, 2014
• Schlumberger M, Tahara M, Wirth LJ, et al.: Lenvatinib versus placebo in radioiodine-refractory thyroid cancer. N Engl J Med 372: 621-630, 2015
• Vicari L, Colarossi C, Giuffrida D, De Maria R, Memeo L: Cancer stem cells as a potential therapeutic target in thyroid carcinoma. Oncol Left 12: 2254-2260, 2016
• Bian XH, Sun H, Xue H, Zhang G, Zhang CH, Liu XL, Su J, Li SJ: Expression and clinical significance of Shh/Gli-1 in papillary thyroid carcinoma Tumor Biol 35 : 10523-10528, 2014
• Dong W, Cui J, Tian X, He L, Wang Z, Zhang P, Zhang H: Aberrant sonic hedgehog signaling pathway and STAT3 activation in papillary thyroid cancer. Int J Clin Exp Med 7: 1786-1793, 2014

Terms in the title (6)： 甲状腺 ,  分化 ,  癌細胞 ,  阻害薬 ,  抗腫瘍効果 ,  癌幹細胞