Art

J-GLOBAL ID：201902255555888145   Reference number：19A1249047

Effect of Selective Serotonin (5-HT)_2B Receptor Agonist BW723C86 on Epidermal Growth Factor/Transforming Growth Factor-α Receptor Tyrosine Kinase and Ribosomal p70 S6 Kinase Activities in Primary Cultures of Adult Rat Hepatocytes

成体ラット肝細胞の初代培養における表皮成長因子/形質転換成長因子-α受容体チロシンキナーゼおよびリボソームp70 S6キナーゼ活性に及ぼす選択的セロトニン(5-HT)_2B受容体アゴニストBW723C86の影響

Author (6)： Naito Kota (Departments of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University) ,  Kurihara Kazuki (Departments of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University) ,  Moteki Hajime (Departments of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University) ,  Kimura Mitsutoshi (Departments of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University) ,  Natsume Hideshi (Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Josai University) ,  Ogihara Masahiko (Departments of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 4  Page： 631-637(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Rattus ,...
Semi thesaurus term： cellular signal transduction ,...

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Author keywords (10)： serotonin ,  signal transduction ,  ribosomal p70 S6 kinase (p70S6K) ,  transforming growth factor-α ,  proliferation (cultured hepatocyte) ,  serotonin ,  signal transduction ,  ribosomal p70 S6 kinase (p70S6K) ,  transforming growth factor-α ,  proliferation (cultured hepatocyte)

JST classification (3)： Basic medicine on digestive system  (GH01020E) ,  Basic research of other drugs acting on metabolism  (GW13060I) ,  Cell physiology in general  (EF02010S)

Substance index (5)： BAPTA-AM ,  BW-723C86 ,  LY-272015 ,  U-73122 ,  LYS6K2

Reference (43)：

• 1) Michalopoulos GK, DeFrances MC. Liver regeneration. Science, 276, 60-66 (1997).
• 2) Fausto N, Campbell JS, Riehle KJ. Liver regeneration. Hepatology, 43 (Suppl. 1), S45-S53 (2006).
• 3) Lesurtel M, Clavien PA. Serotonin: a key molecule in acute and chronic liver injury. Clin. Res. Hepatol. Gastroenterol., 36, 319-322 (2012).
• 4) Murata S, Ohkohchi N, Matsuo R, Ikeda O, Myronovych A, Hoshi R. Platelets promote liver regeneration in early period after hepatectomy in mice. World J. Surg., 31, 808-816 (2007).
• 5) Han X, Chen C, Cheng G, Liang L, Yao G, Yang G, You P, Shou X. Peroxisome proliferator-activated receptor γ attenuates serotonin-induced pulmonary artery smooth muscle cell proliferation and apoptosis inhibition involving ERK1/2 pathway. Microvasc. Res., 100, 17-24 (2015).

Terms in the title (15)： 成体 ,  ラット ,  肝細胞 ,  初代培養 ,  表皮成長因子 ,  形質転換成長因子 ,  受容体チロシンキナーゼ ,  リボソーム ,  p70 ,  S6キナーゼ ,  活性 ,  セロトニン ,  5-HT ,  受容体 ,  アゴニスト