Art

J-GLOBAL ID：201902256112733808   Reference number：19A0217228

Disruption of Gap Junction-Mediated Intercellular Communication in the Spiral Ligament Causes Hearing and Outer Hair Cell Loss in the Cochlea of Mice

螺旋靭帯におけるギャップ結合仲介細胞間コミュニケーションの破壊はマウスの蝸牛における聴覚および外有毛細胞消失を引き起こす

Author (5)： Nishiyama Norito (Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University) ,  Yamaguchi Taro (Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University) ,  Yoneyama Masanori (Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University) ,  Onaka Yusuke (Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University) ,  Ogita Kiyokazu (Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 1  Page： 73-80(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： *cellular signal transduction ,...

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Author keywords (10)： carbenoxolone ,  gap junction-mediated intercellular communication ,  4-hydroxynonenal ,  noise-induced hearing loss ,  outer hair cell loss ,  carbenoxolone ,  gap junction-mediated intercellular communication ,  4-hydroxynonenal ,  noise-induced hearing loss ,  outer hair cell loss

JST classification (2)： Basic otorhinolaryngology  (GQ01020F) ,  Auditory sense  (EJ13030M)

Substance index (3)： 4-Hydroxy-2-nonenal ,  SIN-1 ,  Carbenoxolone

Reference (37)：

• 1) Kumar NM, Gilula NB. The gap junction communication channel. Cell, 84, 381-388 (1996).
• 2) Sáez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC. Plasma membrane channels formed by connexins: their regulation and functions. Physiol. Rev., 83, 1359-1400 (2003).
• 3) Yao J, Zhu Y, Morioka T, Oite T, Kitamura M. Pathophysiological roles of gap junction in glomerular mesangial cells. J. Membr. Biol., 217, 123-130 (2007).
• 4) Yao J, Oite T, Kitamura M. Gap junctional intercellular communication in the juxtaglomerular apparatus. Am. J. Physiol., 296, F939-F946 (2009).
• 5) Ahmad S, Chen S, Sun J, Lin X. Connexins 26 and 30 are co-assembled to form gap junctions in the cochlea of mice. Biochem. Biophys. Res. Commun., 307, 362-368 (2003).

Terms in the title (10)： 螺旋 ,  靭帯 ,  ギャップ結合 ,  仲介 ,  細胞間コミュニケーション ,  破壊 ,  マウス ,  蝸牛 ,  聴覚 ,  外有毛細胞