Art

J-GLOBAL ID：201902256579649965   Reference number：19A0718895

SIRT1/AMPK and Akt/eNOS signaling pathways are involved in endothelial protection of total aralosides of Aralia elata (Miq) Seem against high-fat diet-induced atherosclerosis in ApoE-/- mice

SIRT1/AMPKおよびAkt/eNOSシグナル伝達経路はApoE-/-マウスにおける高脂肪食誘発性アテローム性動脈硬化症に対するAralia elata(MiQ)SEEMの総アラロシドの内皮保護に関与する【JST・京大機械翻訳】

Author (25)： Luo Yun (Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China) ,  Luo Yun (Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, China) ,  Luo Yun (Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, China) ,  Luo Yun (Key Laboratory of Efficacy Evaluation of Chinese Medicine Against Glyeolipid Metabolism Disorder Disease, State Administration of Traditional Chinese Medicine, Beijing, China) ,  Lu Shan (Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China) ,  Lu Shan (Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, China) ,  Lu Shan (Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, China) ,  Lu Shan (Key Laboratory of Efficacy Evaluation of Chinese Medicine Against Glyeolipid Metabolism Disorder Disease, State Administration of Traditional Chinese Medicine, Beijing, China) ,  Ai Qidi (School of Pharmaceutical Science, Hunan University of Chinese Medicine, Changsha, China) ,  Zhou Ping (Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China) ,  Zhou Ping (Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, China) ,  Zhou Ping (Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, China) ,  Zhou Ping (Key Laboratory of Efficacy Evaluation of Chinese Medicine Against Glyeolipid Metabolism Disorder Disease, State Administration of Traditional Chinese Medicine, Beijing, China) ,  Qin Meng (Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China) ,  Qin Meng (Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, China) ,  Qin Meng (Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, China) ,  Qin Meng (Key Laboratory of Efficacy Evaluation of Chinese Medicine Against Glyeolipid Metabolism Disorder Disease, State Administration of Traditional Chinese Medicine, Beijing, China) ,  Sun Guibo (Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China) ,  Sun Guibo (Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, China) ,  Sun Guibo (Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, China) ,  Sun Guibo (Key Laboratory of Efficacy Evaluation of Chinese Medicine Against Glyeolipid Metabolism Disorder Disease, State Administration of Traditional Chinese Medicine, Beijing, China) ,  Sun Xiaobo (Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China) ,  Sun Xiaobo (Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, China) ,  Sun Xiaobo (Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, China) ,  Sun Xiaobo (Key Laboratory of Efficacy Evaluation of Chinese Medicine Against Glyeolipid Metabolism Disorder Disease, State Administration of Traditional Chinese Medicine, Beijing, China)
Material： Phytotherapy Research  (Phytother Res)
Volume： 33  Issue： 3  Page： 768-778  Publication year： 2019 
JST Material Number： W0135A  ISSN： 0951-418X  CODEN： PHYREH  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Total aralosides of Aralia ela...

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Thesaurus term： in vitro experiment ,  anti-inflammatory action ,  apoptosis ,  *high fat diet ,  human(primates) ,  antioxidation ,  *Aralia ,  siRNA ,  endothelial cell ,  *atherosclerosis ,  *endothelium ,  therapy
Semi thesaurus term： 抗アポトーシス作用 ,  *伝達経路 ,  *一酸化窒素シンターゼIII ,  *Akt/蛋白質キナーゼB , 【Automatic Indexing@JST】

Author keywords (6)： Akt/eNOS ,  apoptosis ,  atherosclerosis ,  endothelial cells ,  SIRT1/AMPK ,  TASAES

JST classification (1)： Cell physiology in general  (EF02010S)

Terms in the title (11)： SIRT1 ,  AMPK ,  Akt ,  eNOS ,  シグナル伝達経路 ,  APOE ,  マウス ,  高脂肪食 ,  アテローム性動脈硬化症 ,  Aralia ,  内皮