Art

J-GLOBAL ID：201902256735088006   Reference number：19A2359957

Design, Synthesis, Evaluation, and Structural Studies of C₂-Symmetric Small Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction

プログラム細胞死-1/プログラム死-リガンド1蛋白質-蛋白質相互作用のC_2対称小分子阻害剤の設計,合成,評価,および構造研究【JST・京大機械翻訳】

Author (11)： Basu Subhadwip (Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey) ,  Yang Jeffrey (Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey) ,  Xu Bin (Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey) ,  Magiera-Mularz Katarzyna (Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Poland) ,  Skalniak Lukasz (Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Poland) ,  Musielak Bogdan (Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Poland) ,  Kholodovych Vladyslav (Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey) ,  Kholodovych Vladyslav (Office of Advanced Research Computing, Rutgers, The State University of New Jersey) ,  Holak Tad A. (Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Poland) ,  Hu Longqin (Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey) ,  Hu Longqin (The Cancer Institute of New Jersey, New Jersey, United States)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 62  Issue： 15  Page： 7250-7263  Publication year： 2019 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： A series of C₂-symm...

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Thesaurus term： coculture ,  *Death ,  *interaction ,  *symmetry ,  binding site ,  X-ray ,  NMR ,  Antigens, CD274 ,  co-crystal ,  Programmed Cell Death 1 Receptor ,  inhibitory activity ,  *programmed cell death ,  *protein-protein interaction
Semi thesaurus term： *阻害剤 ,  *小分子阻害剤 , 【Automatic Indexing@JST】

JST classification (2)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Terms in the title (8)： プログラム細胞死 ,  リガンド ,  蛋白質-蛋白質相互作用 ,  対称 ,  小分子阻害剤 ,  設計 ,  評価 ,  研究