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J-GLOBAL ID：201902256997368110   Reference number：19A1806769

Mechanistic Insights into the Activation of Soluble Guanylate Cyclase by Carbon Monoxide: A Multistep Mechanism Proposed for the BAY 41-2272 Induced Formation of 5-Coordinate CO-Heme

一酸化炭素による可溶性グアニル酸シクラーゼの活性化への機構的洞察: 5-配位Co-ヘムのBAY 41-2272誘導形成のために提案された多段階機構【JST・京大機械翻訳】

Author (8)： Makino Ryu (Department of Life Science, College of Science, Rikkyo University, Japan) ,  Obata Yuji (Department of Life Science, College of Science, Rikkyo University, Japan) ,  Tsubaki Motonari (Department of Chemistry, Graduate School of Science, Kobe University, Hyogo, Japan) ,  Iizuka Tetsutaro (RIKEN Harima Institute/Spring8, Hyogo, Japan) ,  Hamajima Yuki (Department of Life Science, College of Science, Rikkyo University, Japan) ,  Kato-Yamada Yasuyuki (Department of Life Science, College of Science, Rikkyo University, Japan) ,  Mashima Keisuke (Department of Life Science, College of Science, Rikkyo University, Japan) ,  Shiro Yoshitsugu (Graduate School of Life Science, University of Hyogo, Hyogo, Japan)
Material： Biochemistry
Volume： 57  Issue： 10  Page： 1620-1631  Publication year： 2018 
JST Material Number： B0270B  ISSN： 0006-2960  CODEN： BICHAW  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Soluble guanylate cyclase (sGC...

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Thesaurus term： intermediate ,  catalyst ,  cleavage reaction ,  *Carbon Monoxide ,  dissociation rate ,  effector ,  enzyme ,  infrared spectrum ,  addition product ,  CO concentration ,  ferrous ,  allosteric modulator ,  *soluble guanylate cyclase ,  guanine nucleotide ,  ribonucleotide ,  cyclic nucleotide

JST classification (1)： Enzyme in general  (EB09010D)

Substance index (2)： cGMP ,  BAY 41-2272

Terms in the title (9)： 一酸化炭素 ,  可溶性グアニル酸シクラーゼ ,  活性化 ,  洞察 ,  CO ,  ヘム ,  誘導 ,  提案 ,  段階