Art

J-GLOBAL ID：201902257853121790   Reference number：19A2183464

Decrease in Intracellular Perforin Levels and IFN-γ Production in Human CD8⁺T Cell Line following Long-Term Exposure to Asbestos Fibers

アスベスト繊維への長期曝露後のヒトCD8+T細胞株における細胞内パーフォリンレベルとIFN-γ産生の減少【JST・京大機械翻訳】

Author (7)： Kumagai-Takei Naoko (Department of Hygiene, Kawasaki Medical School, 701-0192 Kurashiki, Japan) ,  Nishimura Yasumitsu (Department of Hygiene, Kawasaki Medical School, 701-0192 Kurashiki, Japan) ,  Matsuzaki Hidenori (Department of Hygiene, Kawasaki Medical School, 701-0192 Kurashiki, Japan) ,  Matsuzaki Hidenori (Department of Life Science, Faculty of Life and Environmental Science, Prefectural University of Hiroshima, 727-0023 Shobara, Japan) ,  Lee Suni (Department of Hygiene, Kawasaki Medical School, 701-0192 Kurashiki, Japan) ,  Yoshitome Kei (Department of Hygiene, Kawasaki Medical School, 701-0192 Kurashiki, Japan) ,  Otsuki Takemi (Department of Hygiene, Kawasaki Medical School, 701-0192 Kurashiki, Japan)
Material： Journal of Immunology Research (Web)  (J Immunol Res (Web))
Volume： 2018  Page： Null  Publication year： 2018 
JST Material Number： U7019A  ISSN： 2314-8861  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Although the tumorigenicity of...

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Thesaurus term： lymphocyte ,  *interferon gamma ,  mesothelioma ,  tumor immunity ,  *human(primates) ,  *perforin ,  antibody ,  CD3 antigen ,  *asbestos ,  enol ,  carboxylic acid ,  diene ,  oxygen heterocyclic compound ,  enone ,  polyol
Semi thesaurus term： グランザイムB ,  クリソタイル ,  *CD8陽性細胞 ,  *CD8陽性T細胞 ,  *長期曝露 , 【Automatic Indexing@JST】

JST classification (2)： Immunological reaction in general  (ED03010T) ,  Basic research of immunotherapeutic agents and blood preparations  (GW22010D)

Substance index (1)： Ionomycin

Reference (33)：

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• M. Stanton, M. Layard, A. Tegeris, E. Miller, M. May, E. Morgan, A. Smith, "Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals," JNCI: Journal of the National Cancer Institute, vol. 67, pp. 965-975, 1981.
• G. Guthrie Jr., "Mineral properties and their contributions to particle toxicity," Environmental Health Perspectives, vol. 105, pp. 1003-1011, 1997.
• M. Dušinská, A. Collins, A. Kažimı́rová, M. Barančoková, V. Harrington, K.́. Volkovová, M. Staruchová, A. Horská, L. Wsólová, A. Kočan, J. Petrı́k, M. Machata, B. Ratcliffe, S. Kyrtopoulos, "Genotoxic effects of asbestos in humans," Mutation Research, vol. 553, no. 1-2, pp. 91-102, 2004.

Terms in the title (8)： アスベスト ,  繊維 ,  長期曝露 ,  ヒト ,  CD8+T細胞 ,  株 ,  パーフォリン ,  IFN-γ