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J-GLOBAL ID：201902257970926253   Reference number：19A1777769

Identification by nano-LC-MS/MS of NT5DC2 as a protein binding to tyrosine hydroxylase: Down-regulation of NT5DC2 by siRNA increases catecholamine synthesis in PC12D cells

チロシン水酸化酵素への蛋白質結合としてのNT5DC2のナノLC-MS/MSによる同定: siRNAによるNT5DC2のダウンレギュレーションはPC12D細胞におけるカテコールアミン合成を増加させる【JST・京大機械翻訳】

Author (8)： Nakashima Akira (Department Physiological Chemistry, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan) ,  Yamaguchi Hisateru (Division of Biomedical Polymer Science, Institute of Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan) ,  Kodani Yu (Department Physiology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan) ,  Kaneko Yoko S. (Department Physiology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan) ,  Kawata Miho (Department Physiology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan) ,  Nagasaki Hiroshi (Department Physiology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan) ,  Nagatsu Toshiharu (Fujita Health University, School of Medicine, Toyoake, Aichi, Japan) ,  Ota Akira (Department Physiology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 516  Issue： 4  Page： 1060-1065  Publication year： 2019 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Tyrosine hydroxylase (TH), whi...

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Thesaurus term： complex(substance) ,  antibody ,  *siRNA ,  Western blotting ,  gene ,  *down-regulation ,  phosphatase ,  rate-limiting ,  *catecholamine ,  nucleotidase ,  catalyst ,  *protein ,  biosynthesis ,  primary amine
Semi thesaurus term： α-シヌクレイン , 【Automatic Indexing@JST】

Author keywords (6)： GWAS ,  NT5DC2 ,  Schizophrenia ,  Tyrosine hydroxylase ,  5′-nucleotidase domain-containing protein 2 ,  Dopamine

JST classification (5)： Enzyme in general  (EB09010D) ,  Enzyme physiology  (EJ02020P) ,  Function of cell components  (EF03060C) ,  Gene expression  (EC02040Q) ,  Nervous system diseases  (GN03000O)

Substance index (1)： Dopamine

Terms in the title (8)： チロシン水酸化酵素 ,  蛋白質結合 ,  LC-MS ,  同定 ,  siRNA ,  ダウンレギュレーション ,  PC12D細胞 ,  カテコールアミン