Art

J-GLOBAL ID：201902258215050886   Reference number：19A1552497

The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity

異なるヒト集団におけるAPOEの遺伝的多様性とその寿命に対する意味【JST・京大機械翻訳】

Author (9)： Abondio Paolo (Laboratory of Molecular Anthropology & Centre for Genome Biology, Department of Biological, Geological and Environmental Sciences, University of Bologna, 40126 Bologna, Italy) ,  Sazzini Marco (Laboratory of Molecular Anthropology & Centre for Genome Biology, Department of Biological, Geological and Environmental Sciences, University of Bologna, 40126 Bologna, Italy) ,  Garagnani Paolo (Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, 40126 Bologna, Italy) ,  Boattini Alessio (Laboratory of Molecular Anthropology & Centre for Genome Biology, Department of Biological, Geological and Environmental Sciences, University of Bologna, 40126 Bologna, Italy) ,  Monti Daniela (Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50134 Florence, Italy) ,  Franceschi Claudio (IRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy) ,  Luiselli Donata (Department of Cultural Heritage (DBC), University of Bologna, Ravenna Campus, 48121 Ravenna, Italy) ,  Giuliani Cristina (Laboratory of Molecular Anthropology & Centre for Genome Biology, Department of Biological, Geological and Environmental Sciences, University of Bologna, 40126 Bologna, Italy) ,  Giuliani Cristina (School of Anthropology and Museum Ethnography, University of Oxford, OX2 6PE Oxford, UK)
Material： Genes (Web)
Volume： 10  Issue： 3  Page： 222  Publication year： 2019 
JST Material Number： U7194A  ISSN： 2073-4425  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Human longevity is a complex p...

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Thesaurus term： interaction ,  allele ,  aggregation ,  *apo E ,  haplotype ,  *human(primates) ,  gene ,  database ,  ecology(science) ,  Alzheimer disease ,  phenotype ,  Genome-Wide Association Study
Semi thesaurus term： ゲノム配列 , 【Automatic Indexing@JST】

Author keywords (5)： apolipoprotein E ,  APOE ,  longevity ,  populations ,  genomics

JST classification (1)： Gene expression  (EC02040Q)

Reference (262)：

• Blue, M.L.; Williams, D.L.; Zucker, S.; Khan, S.A.; Blum, C.B. Apolipoprotein E synthesis in human kidney, adrenal gland, and liver. Proc. Natl. Acad. Sci. USA 1983, 80, 283-287.
• Kockx, M.; Traini, M.; Kritharides, L. Cell-specific production, secretion, and function of apolipoprotein E. J. Mol. Med. 2018, 96, 361-371.
• Tedla, N.; Glaros, E.N.; Brunk, U.T.; Jessup, W.; Garner, B. Heterogeneous expression of apolipoprotein-E by human macrophages. Immunology 2004, 113, 338-347.
• Boyles, J.K.; Pitas, R.E.; Wilson, E.; Mahley, R.W.; Taylor, J.M. Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J. Clin. Investig. 1985, 76, 1501-1513.
• Wetterau, J.R.; Aggerbeck, L.P.; Rall, S.C.; Weisgraber, K.H. Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains. J. Biol. Chem. 1988, 263, 6240-6248.

Terms in the title (6)： ヒト ,  集団 ,  APOE ,  遺伝的多様性 ,  寿命 ,  意味