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J-GLOBAL ID：201902258332875596   Reference number：19A2352492

Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a “Tail Switching” Strategy on a Piperazinyl Azetidine Skeleton

ピペラジニルアゼチジン骨格における”尾部スイッチング”戦略を用いた可逆的および不可逆的モノアシルグリセロールリパーゼ陽電子放出断層撮影(PET)トレーサの設計,合成および評価【JST・京大機械翻訳】

Author (35)： Chen Zhen (Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Massachusetts, United States) ,  Chen Zhen (Department of Chemistry, School of Science, Tianjin University, China) ,  Mori Wakana (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Japan) ,  Deng Xiaoyun (Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Massachusetts, United States) ,  Cheng Ran (Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Massachusetts, United States) ,  Ogasawara Daisuke (The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, California, United States) ,  Zhang Genwei (Department of Chemistry and Biochemistry, University of Oklahoma, Oklahoma, United States) ,  Schafroth Michael A. (The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, California, United States) ,  Dahl Kenneth (Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Massachusetts, United States) ,  Fu Hualong (Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Massachusetts, United States) ,  Hatori Akiko (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Japan) ,  Shao Tuo (Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Massachusetts, United States) ,  Zhang Yiding (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Japan) ,  Yamasaki Tomoteru (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Japan) ,  Zhang Xiaofei (Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Massachusetts, United States) ,  Rong Jian (Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Massachusetts, United States) ,  Yu Qingzhen (Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Massachusetts, United States) ,  Hu Kuan (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Japan) ,  Fujinaga Masayuki (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Japan) ,  Xie Lin (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Japan) ,  Kumata Katsushi (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Japan) ,  Gou Yuancheng (ChemShuttle, Inc., Jiangsu, China) ,  Chen Jingjin (ChemShuttle, Inc., Jiangsu, China) ,  Gu Shuyin (ChemShuttle, Inc., Jiangsu, China) ,  Bao Liang (ChemShuttle, Inc., Jiangsu, China) ,  Wang Lu (Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Massachusetts, United States) ,  Collier Thomas Lee (Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Massachusetts, United States) ,  Vasdev Neil (Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Massachusetts, United States) ,  Shao Yihan (Department of Chemistry and Biochemistry, University of Oklahoma, Oklahoma, United States) ,  Ma Jun-An (Department of Chemistry, School of Science, Tianjin University, China) ,  Cravatt Benjamin F. (The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, California, United States) ,  Fowler Christopher (Department of Pharmacology and Clinical Neuroscience, Umea University, Sweden) ,  Josephson Lee (Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Massachusetts, United States) ,  Zhang Ming-Rong (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Japan) ,  Liang Steven H. (Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Massachusetts, United States)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 62  Issue： 7  Page： 3336-3353  Publication year： 2019 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Monoacylglycerol lipase (MAGL)...

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Thesaurus term： Inflammation ,  human ,  *irreversibility ,  *switching ,  *PET (tomography) ,  therapy ,  organ ,  radioligand ,  binding specificity ,  Chronic Pain ,  serine hydrolase ,  Endocannabinoids ,  *Monoacylglycerol Lipases
Semi thesaurus term： 阻害剤 ,  神経変性 , 【Automatic Indexing@JST】

JST classification (2)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Physicochemical pharmacy in general  (GV01010J)

Terms in the title (10)： 骨格 ,  尾部 ,  スイッチング ,  戦略 ,  モノアシルグリセロールリパーゼ ,  陽電子放出断層撮影 ,  PET ,  トレーサ ,  設計 ,  評価