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J-GLOBAL ID：201902258598424231   Reference number：19A0791670

Suppression of AKT-mTOR signal pathway enhances osteogenic/dentinogenic capacity of stem cells from apical papilla

Akt-mTORシグナル経路の抑制は頂端乳頭からの幹細胞の骨形成/象牙質形成能を増強する【JST・京大機械翻訳】

Author (13)： Tanaka Yosuke (Division of Oral Biological Sciences, Department of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, Fukuoka, Japan) ,  Sonoda Soichiro (Division of Oral Biological Sciences, Department of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, Fukuoka, Japan) ,  Yamaza Haruyoshi (Division of Oral Health, Department of Pediatric Dentistry, Growth & Development, Kyushu University Graduate School of Dental Science, Fukuoka, Japan) ,  Murata Sara (Division of Oral Biological Sciences, Department of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, Fukuoka, Japan) ,  Nishida Kento (Division of Oral Biological Sciences, Department of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, Fukuoka, Japan) ,  Nishida Kento (Kyushu University School of Dentistry, Fukuoka, Japan) ,  Hama Shion (Division of Oral Biological Sciences, Department of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, Fukuoka, Japan) ,  Hama Shion (Kyushu University School of Dentistry, Fukuoka, Japan) ,  Kyumoto-Nakamura Yukari (Division of Oral Biological Sciences, Department of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, Fukuoka, Japan) ,  Uehara Norihisa (Division of Oral Biological Sciences, Department of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, Fukuoka, Japan) ,  Nonaka Kazuaki (Division of Oral Health, Department of Pediatric Dentistry, Growth & Development, Kyushu University Graduate School of Dental Science, Fukuoka, Japan) ,  Kukita Toshio (Division of Oral Biological Sciences, Department of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, Fukuoka, Japan) ,  Yamaza Takayoshi (Division of Oral Biological Sciences, Department of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, Fukuoka, Japan)
Material： Stem Cell Research & Therapy (Web)
Volume： 9  Issue： 1  Page： 334  Publication year： 2018 
JST Material Number： U7397A  ISSN： 1757-6512  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Stem cells from apical papilla...

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Thesaurus term： human ,  *Dentin ,  pretreatment ,  calcification ,  differentiation (biology) ,  in vitro experiment ,  mesenchymal cell ,  Phosphatidylinositol 3-Kinase ,  Mammalia ,  *osteogenesis ,  siRNA ,  molecular mechanism ,  *TOR Serine-Threonine Kinases ,  *signal transduction pathway ,  Vertebrata ,  ether ,  macrocyclic compound ,  lactam ,  lactone ,  enzyme inhibitor ,  hemiacetal ,  alicyclic alcohol ,  secondary alcohol ,  hydroxy ketone
Semi thesaurus term： *伝達経路 , 【Automatic Indexing@JST】

Author keywords (5)： Stem cells from apical papilla (SCAP) ,  Phosphoinositide 3 kinase (PI3K) ,  AKT ,  Mammalian target of rapamycin (mTOR) ,  Scaffold-free spheroidal calcified construct

JST classification (1)： Cell physiology in general  (EF02010S)

Substance index (1)： Sirolimus

Reference (45)：

• PLoS One; Mesenchymal stem cell-mediated functional tooth regeneration in swine; W Sonoyama; 1; 2006; e79; 10.1371/journal.pone.0000079; citation_id=CR1
• Arch Oral Biol; Comparison of osteo/dentinogenic differentiation of human adult dental pulp stem cells and stem cells from apical papilla in the presence of platelet lysate; D Abuarqoub, A Awidi, N Abuharfeil; 60; 2015; 1545-1553; 10.1016/j.archoralbio.2015.07.007; citation_id=CR2
• Development; Cellular and molecular mechanisms of tooth root development; J Li, C Parada, Y Chai; 144; 2017; 374-384; 10.1242/dev.137216; citation_id=CR3
• Cancer Cell; The Akt-mTOR tango and its relevance to cancer; N Hay; 8; 2005; 179-183; 10.1016/j.ccr.2005.08.008; citation_id=CR4
• Stem Cell Res Ther; Immunomodulatory properties of stem cells from human exfoliated deciduous teeth; T Yamaza; 1; 2010; 5; 10.1186/scrt5; citation_id=CR5

Terms in the title (8)： Akt ,  mTOR ,  シグナル経路 ,  乳頭 ,  幹細胞 ,  骨形成 ,  象牙質 ,  増強