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J-GLOBAL ID：201902259104946896   Reference number：19A2290034

EK7 Regulates NLRP3 Inflammasome Activation and Neuroinflammation Post-traumatic Brain Injury

Ek7はNLRP3インフラマソーム活性化と神経炎症後外傷性脳損傷を調節する【JST・京大機械翻訳】

Author (10)： Chen Yuhua (Department of Central Laboratory, Xi’an Peihua University, Xi’an, China) ,  Chen Yuhua (Department of Neurosurgery, the Second Affiliated Hospital of Xi’an Medical University, Xi’an, China) ,  Meng Jiao (Department of Central Laboratory, Xi’an Peihua University, Xi’an, China) ,  Meng Jiao (Department of Basic Medical Science Research Center, Shaanxi Fourth People’s Hospital, Xi’an, China) ,  Bi Fangfang (Department of Central Laboratory, Xi’an Peihua University, Xi’an, China) ,  Bi Fangfang (Department of Basic Medical Science Research Center, Shaanxi Fourth People’s Hospital, Xi’an, China) ,  Li Hua (Department of Basic Medical Science Research Center, Shaanxi Fourth People’s Hospital, Xi’an, China) ,  Chang Cuicui (Department of Central Laboratory, Xi’an Peihua University, Xi’an, China) ,  Ji Chen (Department of Central Laboratory, Xi’an Peihua University, Xi’an, China) ,  Liu Wei (Department of Neurosurgery, the Second Affiliated Hospital of Xi’an Medical University, Xi’an, China)
Material： Frontiers in Molecular Neuroscience (Web)
Volume： 12  Page： 202  Publication year： 2019 
JST Material Number： U7082A  ISSN： 1662-5099  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： As one of the most common caus...

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Thesaurus term： up-regulation ,  oligomerization ,  time dependence ,  *brain damage ,  caspase ,  interleukin 1 ,  down-regulation ,  neuron ,  in vitro experiment
Semi thesaurus term： ピロトーシス ,  遺伝子ノックダウン法 ,  低分子ヘアピンRNA ,  ドメイン構造 ,  *神経系炎症 ,  *インフラマソーム , 【Automatic Indexing@JST】

Author keywords (7)： traumatic brain injury ,  NLRP3 inflammasome ,  NEK7 ,  caspase-1 activation ,  pyroptosis ,  potassium efflux ,  neuroinflammation

JST classification (1)： Cell physiology in general  (EF02010S)

Reference (52)：

• Adamczak S. E., de Rivero Vaccari J. P., Dale G., Brand F. J., Nonner D., Bullock M. R., et al. (2014). Pyroptotic neuronal cell death mediated by the AIM2 inflammasome inflammasome. J. Cereb. Blood Flow Metab. 34, 621-629. doi: 10.1038/jcbfm.2013.236
• Barlow K. M., Esser M. J., Veidt M., Boyd R. (2018). Melatonin as a treatment after traumatic brain injury: a systematic review and meta-analysis of the pre-clinical and clinical literature. J. Neurotrauma 36, 523-537. doi: 10.1089/neu.2018.5752
• Cederberg D., Siesjö P. (2010). What has inflammation to do with traumatic brain injury? Childs Nerv. Syst. 26, 221-226. doi: 10.1007/s00381-009-1029-x
• Chen Y. H., Meng J., Xu Q. H., Long T. L., Bi F. F., Chang C. C., et al. (2019). Rapamycin improves the neuroprotection effect of inhibition of NLRP3 inflammasome activation after TBI. Brain Res. 1710, 163-172. doi: 10.1016/j.brainres.2019.01.005
• Eder C. (2009). Mechanisms of interleukin-1β release. Immunobiology 214, 543-553. doi: 10.1016/j.imbio.2008.11.007

Terms in the title (5)： NLRP3インフラマソーム ,  活性化 ,  神経炎症 ,  外傷性脳損傷 ,  調節