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J-GLOBAL ID：201902259424530845   Reference number：19A0881840

Anti-Tumorigenic Activity of Chrysin from Oroxylum indicum via Non-Genotoxic p53 Activation through the ATM-Chk2 Pathway

ATM-Chk2経路を介した非遺伝毒性p53活性化を介したOroxylumindicumからのクリシンの抗腫瘍形成活性【JST・京大機械翻訳】

Author (14)： Nagasaka Mai (Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan) ,  Hashimoto Ryoko (Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan) ,  Inoue Yasumichi (Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan) ,  Inoue Yasumichi (Department of Innovative Therapeutic Sciences, Cooperative Major in Nanopharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan) ,  Ishiuchi Kan'ichiro (Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University; Nagoya 467-8603, Japan) ,  Matsuno Michiyo (The Kochi Prefectural Makino Botanical Garden, Kochi 781-8125, Japan) ,  Itoh Yuka (Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan) ,  Tokugawa Muneshige (Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan) ,  Ohoka Nobumichi (Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, Kawasaki 210-9501, Japan) ,  Morishita Daisuke (Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan) ,  Mizukami Hajime (The Kochi Prefectural Makino Botanical Garden, Kochi 781-8125, Japan) ,  Makino Toshiaki (Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University; Nagoya 467-8603, Japan) ,  Hayashi Hidetoshi (Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan) ,  Hayashi Hidetoshi (Department of Innovative Therapeutic Sciences, Cooperative Major in Nanopharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan)
Material： Molecules (Web)
Volume： 23  Issue： 6  Page： 1394  Publication year： 2018 
JST Material Number： U7014A  ISSN： 1420-3049  CODEN： MOLEFW  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The p53 tumor suppressor plays...

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Thesaurus term： *p53 protein ,  carcinogenesis ,  screening(inspection) ,  apoptosis ,  MCF7 cell ,  luciferase ,  flavonoid ,  antitumor drug ,  wild type ,  *genetic toxicity ,  DNA lesion ,  oxygen heterocyclic compound ,  polyphenol ,  polynuclear aromatic compound ,  hydroxy ketone
Semi thesaurus term： *Oroxylum ,  蛋白質発現 ,  抽出物 , 【Automatic Indexing@JST】

Author keywords (6)： Oroxylum indicum ,  chrysin ,  p53 ,  ATM ,  Chk2 ,  flavonoid

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic research of pharmacology of crude drugs  (GX06020J)

Substance index (1)： Chrysin

Reference (41)：

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• Fridman, J.S.; Lowe, S.W. Control of apoptosis by p53. Oncogene 2003, 22, 9030-9040.
• Vousden, K.H.; Prives, C. Blinded by the light: The growing complexity of p53. Cell 2009, 137, 413-431.
• Menedez, D.; Inga, A.; Resnick, M.A. The expanding universe of p53 targets. Nat. Rev. Cancer 2009, 9, 724-737.
• Burgess, A.; Chia, K.M.; Haupt, S.; Thomas, D.; Haupt, Y.; Lim, E. Clinical overview of MDM2/X-targeted therapies. Front. Oncol. 2016, 6, 7.

Terms in the title (9)： ATM ,  Chk2 ,  経路 ,  遺伝毒性 ,  p53 ,  活性化 ,  クリシン ,  抗腫瘍形成 ,  活性