Art

J-GLOBAL ID：201902259474701567   Reference number：19A1423463

Influence of lysine residue in amphipathic helical peptides on targeted delivery of RNA into cancer cells

癌細胞へのRNAの標的化デリバリーに及ぼす両親媒性ヘリックスペプチドにおけるリジン残基の影響【JST・京大機械翻訳】

Author (8)： Wada Shun-ichi (Department of Bioorganic Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan) ,  Taniguchi Kohei (Department of General and Gastroenterological Surgery, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan) ,  Taniguchi Kohei (Translational Research Program, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan) ,  Hamazaki Hiroaki (Department of Bioorganic Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan) ,  Yamada Azusa (Department of Bioorganic Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan) ,  Hayashi Junsuke (Department of Bioorganic Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan) ,  Uchiyama Kazuhisa (Department of General and Gastroenterological Surgery, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan) ,  Urata Hidehito (Department of Bioorganic Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 29  Issue： 15  Page： 1934-1937  Publication year： 2019 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The cRGD-conjugated Aib-contai...

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Thesaurus term： *peptide ,  *targeting ,  conjugation ,  *tumor cell ,  siRNA ,  *amphiphilic ,  hydrophobic ,  *RNA ,  protein expression ,  endogenous ,  MicroRNAs ,  *Lys residue
Semi thesaurus term： 正常細胞 ,  *残基 ,  siRNAデリバリー , 【Automatic Indexing@JST】

Author keywords (7)： Amphipathic helical peptide ,  α-Aminoisobutyric acid (Aib) ,  Cell-penetrating peptide (CPP) ,  RGD ,  siRNA ,  microRNA ,  Cell selectivity

JST classification (1)： Synthesis of drugs  (GV01030F)

Terms in the title (6)： 癌細胞 ,  RNA ,  標的化 ,  デリバリー ,  両親媒性 ,  リジン残基