Art

J-GLOBAL ID：201902260022116846   Reference number：19A1328471

Anti-proliferative Activities towards Human Brain Glioma U251 Cells and Human Carcinoma Cells (KB3-1) of Some Twin-Drug Type Bivalent C₂-Symmetrical Phenylboronic Acid Derivatives

いくつかの二剤型二価C₂-対称フェニルボロン酸誘導体のヒト脳神経膠腫U251細胞およびヒト癌細胞(KB3-1)に対する抗増殖活性

Author (11)： Furutachi Makoto (Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Gondo Toshiaki (Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Ikeda Ryuji (Department of Pharmacy, University of Miyazaki Hospital) ,  Yoshikawa Naoki (Department of Pharmacy, University of Miyazaki Hospital) ,  Yokota Tsubasa (Department of Pharmacy, University of Miyazaki Hospital) ,  Takeda Yasuo (Kagoshima University Hospital) ,  Yokomizo Kazumi (Faculty of Pharmaceutical Sciences, Sojo University) ,  Zhou Jian-Rong (Faculty of Pharmaceutical Sciences, Sojo University) ,  Kashige Nobuhiro (Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Miake Fumio (Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Sumoto Kunihiro (Faculty of Pharmaceutical Sciences, Fukuoka University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 5  Page： 833-836(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： tumor cell ,...
Semi thesaurus term： KB3-1細胞 ,...

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Author keywords (12)： phenylboronic acid ,  C₂-symmetry ,  anti-proliferative activity ,  U251 cell ,  KB3-1 cell ,  cytotoxic activity ,  phenylboronic acid ,  C₂-symmetry ,  anti-proliferative activity ,  U251 cell ,  KB3-1 cell ,  cytotoxic activity

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Substance index (2)： Phenylboronic acid ,  N,N′-Bis[3-(dihydroxyboryl)phenyl]sebacamide

Reference (22)：

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• 3) Gibson SE, Castaldi MP. C3 symmetry: molecular design inspired by Nature. Angew. Chem. Int. Ed., 45, 4718-4720 (2006).
• 4) Bérubé G. Natural and synthetic biologically active dimeric molecules: anticancer agents, anti-HIV agents, steroid derivatives and opioid antagonists. Curr. Med. Chem., 13, 131-154 (2006).
• 5) Micewicz ED, Luong HT, Jung C-L, Waring AJ, McBride WH, Ruchala P. Novel dimeric Smac analogs as prospective anticancer agents. Bioorg. Med. Chem. Lett., 24, 1452-1457 (2014).

Terms in the title (11)： 剤型 ,  C2 ,  対称 ,  フェニルボロン酸 ,  誘導体 ,  ヒト ,  脳 ,  神経膠腫 ,  U251細胞 ,  癌細胞 ,  抗増殖活性