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J-GLOBAL ID：201902260722553772   Reference number：19A0342931

トリプトファン代謝研究の新しい展開 創薬のターゲットとしてのトリプトファン-キヌレニン代謝経路

Author (3)： FUJIGAKI HIDETSUGU (藤田医大 大学院保健学研究科) ,  YAMAMOTO YASUKO (藤田医大 大学院保健学研究科) ,  SAITO KUNIAKI (藤田医大 大学院保健学研究科)
Material： 臨床化学  (Japanese Journal of Clinical Chemistry)
Volume： 48  Issue： 1  Page： 28-33  Publication year： Jan. 31, 2019 
JST Material Number： Z0312B  ISSN： 0370-5633  CODEN： RIKAAN  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： tumor immunity ,...
Semi thesaurus term： *Drug target ,...

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JST classification (1)： Physicochemical pharmacy in general  (GV01010J)

Substance index (3)： Kynurenine ,  Tryptophan ,  N-(3-Bromo-4-fluorophenyl)-N′-hydroxy-4-[[2-(sulfamoylamino)ethyl]amino]-1,2,5-oxadiazole-3-carboxamidine

Reference (31)：

• Stone TW, Darlington LG: Endogenous kynurenines as targets for drug discovery and development, Nat Rev Drug Discov, 1: 609-620, 2002.
• Fujigaki H, Yamamoto Y, Saito K: L-tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: Focus on cell type differences, Neuropharmacology, 112: 264-274, 2017.
• Miller CL, Llenos IC, Dulay JR, Barillo MM, Yolken RH, Weis S: Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia, Neurobiol Dis, 15: 618-629, 2004.
• Fujigaki H, Saito K, Fujigaki S, Takemura M, Sudo K, Ishiguro H, et al.: The signal transducer and activator of transcription 1alpha and interferon regulatory factor 1 are not essential for the induction of indoleamine 2,3-dioxygenase by lipopolysaccharide: Involvement of p38 mitogen-activated protein kinase and nuclear factor-kappab pathways, and synergistic effect of several proinflammatory cytokines, J Biochem, 139: 655-662, 2006.
• Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, et al.: Prevention of allogeneic fetal rejection by tryptophan catabolism, Science, 281: 1191-1193, 1998.

Terms in the title (8)： トリプトファン ,  代謝 ,  研究 ,  展開 ,  創薬 ,  ターゲット ,  キヌレニン ,  代謝経路