Art

J-GLOBAL ID：201902260859385928   Reference number：19A1861531

Falsely elevated plasma ACTH levels measured by the Elecsys assay related to heterophilic antibody in a case of secondary adrenocortical insufficiency

二次性副腎皮質不全症の症例における異好性抗体に関連したエクルーシス法により測定したACTH血漿中濃度の偽上昇

Author (8)： Morita Koji (Division of Endocrinology and Metabolism, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173-8606, Japan) ,  Ogawa Masumi (Division of Metabolism, Department of Internal Medicine, Self-Defense Forces Central Hospital, Tokyo 154-8532, Japan) ,  Kimura Michiko (Department of Laboratory Medicine, Teikyo University School of Medicine, Tokyo 173-8606, Japan) ,  Okawa Yuta (Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan) ,  Oki Yutaka (Department of Family and Community Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan) ,  Edo Naoki (Division of Endocrinology and Metabolism, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173-8606, Japan) ,  Tsukamoto Kazuhisa (Division of Endocrinology and Metabolism, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173-8606, Japan) ,  Ishikawa Toshio (Division of Endocrinology and Metabolism, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173-8606, Japan)
Material： Endocrine Journal (Web)
Volume： 66  Issue： 6  Page： 563-569(J-STAGE)  Publication year： 2019 
JST Material Number： U1479A  ISSN： 1348-4540  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *Secondary adrenocortical insufficiency ,...

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Author keywords (5)： Adrenocorticotropic hormone (ACTH) ,  Adrenal insufficiency ,  The Elecsys ACTH assay ,  Heterophilic antibody ,  Prolonged ACTH stimulation test

JST classification (3)： Clinical application of diagnostic drugs  (GW20020A) ,  Blood tests(=hematologic tests)  (GC02050D) ,  Endocrine system diagnosis  (GL02000B)

Substance index (1)： Cortisol

Reference (19)：

• 1 Revet I, Boesten LS, Linthorst J, Yildiz E, Janssen JW, et al. (2016) Misleading FT4 measurement: assay-dependent antibody interference. Biochem Med (Zagreb) 26: 436-443.
• 2 Sturgeon CM, Viljoen A (2011) Analytical error and interference in immunoassay: minimizing risk. Ann Clin Biochem 48: 418-432.
• 3 Bolstad N, Kazaryan AM, Revheim ME, Distante S, Johnsrud K, et al. (2012) A man with abdominal pain: enough evidence for surgery? Clin Chem 58: 1187-1190.
• 4 Grasko J, Willliams R, Beilin J, Glendenning P, Fermoyle S, et al. (2013) A diagnostic conundrum: heterophilic antibody interference in an adrenocorticotropic hormone immunoassay not detectable using a proprietary heterophile blocking reagent. Ann Clin Biochem 50: 433-437.
• 5 Saiegh L, Odeh M, Chen-Konak L, Elias N, Sheikh-Ahmad M, et al. (2014) A possible analytical and clinical role of endogenous antibodies causing discrepant adrenocorticotropic hormone measurement in a case of ectopic Cushing’s syndrome. Ann Clin Biochem 51: 490-494.

Terms in the title (5)： 二次性副腎皮質不全 ,  症例 ,  異好性抗体 ,  ACTH ,  血漿中濃度