Art

J-GLOBAL ID：201902260863632643   Reference number：19A1532051

Increased Expression of Renal Drug Transporters in a Mouse Model of Familial Alzheimer’s Disease

家族性Alzheimer病のマウスモデルにおける腎臓薬物輸送体の発現増加【JST・京大機械翻訳】

Author (7)： Pan Yijun (Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, Victoria 3052, Australia) ,  Omori Kotaro (Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan) ,  Ali Izna (UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 301 Pharmacy Lane, Chapel Hill, North Carolina 27599) ,  Tachikawa Masanori (Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan) ,  Terasaki Tetsuya (Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan) ,  Brouwer Kim L.R. (UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 301 Pharmacy Lane, Chapel Hill, North Carolina 27599) ,  Nicolazzo Joseph A. (Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, Victoria 3052, Australia)
Material： Journal of Pharmaceutical Sciences  (J Pharm Sci)
Volume： 108  Issue： 7  Page： 2484-2489  Publication year： 2019 
JST Material Number： C0260B  ISSN： 0022-3549  CODEN： JPMSAE  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： It is well established that th...

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Thesaurus term： substrate (biochemistry) ,  *Alzheimer Disease ,  human ,  oral absorption ,  targeting ,  transgenic mouse ,  *Mus musculus ,  Up-Regulation ,  small intestine ,  Blood-Brain Barrier ,  protein expression ,  wild-type mouse ,  organ ,  metabolic enzyme ,  *drug transporter ,  *mouse model ,  *Myomorpha ,  Cardiovascular System

Author keywords (6)： Alzheimer’s disease ,  multidrug resistance-associated protein(s) (MDR) ,  organic anion transporter(s) (OAT) ,  organic cation transporter(s) (OCT) ,  renal transport ,  transporters

JST classification (1)： Basic biopharmacy  (GY01021U)

Terms in the title (5)： 家族性Alzheimer病 ,  マウスモデル ,  腎臓 ,  薬物輸送体 ,  発現