Art

J-GLOBAL ID：201902260925128624   Reference number：19A1801255

Novel therapies for acute myeloid leukemia based on genomic aberrations

ゲノム異常に基づいたAML新規治療

Author (3)： UMEZAWA YOSHIHIRO (東京医科歯科大学医学部附属病院 血液内科) ,  KAWAMATA NORIHIKO (東京医科歯科大学医学部附属病院 血液内科) ,  KAWAMATA NORIHIKO (東京医科歯科大学 造血器疾患免疫治療学教室)
Material： 臨床血液  (Japanese Journal of Clinical Hematology)
Volume： 60  Issue： 6  Page： 594-599(J-STAGE)  Publication year： Jun. 30, 2019 
JST Material Number： Z0688A  ISSN： 0485-1439  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： human ,...
Semi thesaurus term： *genetic variation ,...

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Author keywords (8)： AML ,  Genomic aberrations ,  FLT3 ,  IDH ,  AML ,  Genomic aberrations ,  FLT3 ,  IDH

JST classification (2)： Blood cell tumors(=neoplasms)  (GK04000M) ,  Drug therapy(=pharmacotherapy)for tumors  (GE03032C)

Reference (30)：

• 1) Döhner H, Weisdorf DJ, Bloomfield CD. Acute myeloid leukemia. N Engl J Med. 2015; 373: 1136-1152.
• 2) Davis JR, Benjamin DJ, Jonas BA. New and emerging therapies for acute myeloid leukaemia. J Investig Med. 2018; 66: 1088-1095.
• 3) Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002; 100: 1532-1542.
• 4) Larrosa-Garcia M, Baer MR. FLT3 inhibitors in acute myeloid leukemia: current status and future directions. Mol Cancer Ther. 2017; 16: 991-1001.
• 5) Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood. 2001; 98: 1752-1759.

Terms in the title (3)： ゲノム異常 ,  AML ,  治療