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J-GLOBAL ID：201902261190336228   Reference number：19A1187331

A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles

ヒトIPSC二重レポーター系は異なる機能と薬物応答プロファイルを持つ心臓系統亜集団の精製を可能にする【JST・京大機械翻訳】

Author (47)： Zhang Joe Z. (Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Zhang Joe Z. (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Zhang Joe Z. (Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Termglinchan Vittavat (Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Termglinchan Vittavat (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Termglinchan Vittavat (Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Shao Ning-Yi (Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Shao Ning-Yi (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Shao Ning-Yi (Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Itzhaki Ilanit (Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Itzhaki Ilanit (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Itzhaki Ilanit (Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Liu Chun (Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Liu Chun (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Liu Chun (Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Ma Ning (Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Ma Ning (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Ma Ning (Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Tian Lei (Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Tian Lei (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Tian Lei (Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Wang Vicky Y. (San Francisco VA Medical Center, San Francisco, CA 94121, USA) ,  Wang Vicky Y. (Departments of Surgery and Bioengineering, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Chang Alex C.Y. (Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Chang Alex C.Y. (Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Guo Hongchao (Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Guo Hongchao (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Guo Hongchao (Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Kitani Tomoya (Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Kitani Tomoya (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Kitani Tomoya (Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Wu Haodi (Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Wu Haodi (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Wu Haodi (Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Lam Chi Keung (Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Lam Chi Keung (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Lam Chi Keung (Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Kodo Kazuki (Department of Pediatrics, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Sayed Nazish (Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Sayed Nazish (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Sayed Nazish (Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Blau Helen M. (Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Blau Helen M. (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Blau Helen M. (Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Wu Joseph C. (Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Wu Joseph C. (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Wu Joseph C. (Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA)
Material： Cell Stem Cell
Volume： 24  Issue： 5  Page： 802-811.e5  Publication year： 2019 
JST Material Number： W3106A  ISSN： 1934-5909  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The diversity of cardiac linea...

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Thesaurus term： characterization ,  cardiac myocyte ,  *human(primates) ,  modeling ,  heterogeneity ,  heredity ,  pedigree chart ,  population(statistics) ,  pluripotent stem cell ,  tissue engineering ,  *heart ,  aliphatic amine ,  aliphatic alcohol ,  quaternary ammonium ,  aminoalcohol
Semi thesaurus term： 薬物スクリーニング ,  差次的遺伝子発現 , 【Automatic Indexing@JST】

Author keywords (10)： human first and second heart field ,  epicardial lineage ,  endothelial cell lineage ,  TBX5 ,  NKX2-5 ,  hiPSC double reporter ,  cardiomyocyte subtypes ,  purification ,  CORIN ,  precise drug testing

JST classification (1)： Gene expression  (EC02040Q)

Substance index (1)： Choline

Terms in the title (8)： ヒト ,  IPSC ,  薬物応答 ,  プロファイル ,  心臓 ,  系統 ,  亜集団 ,  精製