Art

J-GLOBAL ID：201902261424809176   Reference number：19A0217115

A Facile and Convenient Synthesis of Trisubstituted (E)-α,β-Unsaturated Esters by Tandem Acetylation-E1cB Reaction

タンデムアセチル化-E1cB反応による三置換(E)-α,β-不飽和エステルの容易で簡便な合成

Author (15)： Ozeki Minoru (Department of Medicinal and Synthetic Chemistry, Faculty of Pharmaceutical Sciences, Mukogawa Women’s University) ,  Hachino Ayumi (Department of Medicinal and Synthetic Chemistry, Faculty of Pharmaceutical Sciences, Mukogawa Women’s University) ,  Shigeta Takashi (Department of Medicinal and Synthetic Chemistry, Faculty of Pharmaceutical Sciences, Mukogawa Women’s University) ,  Niki Aya (Department of Medicinal and Synthetic Chemistry, Faculty of Pharmaceutical Sciences, Mukogawa Women’s University) ,  Kobayashi Natsuko (Department of Medicinal and Synthetic Chemistry, Faculty of Pharmaceutical Sciences, Mukogawa Women’s University) ,  Mizutani Hideki (Department of Pharmaceutical Manufacturing Chemistry, Kyoto Pharmaceutical University) ,  Nakamura Akihiro (Department of Pharmaceutical Manufacturing Chemistry, Kyoto Pharmaceutical University) ,  Horie Ayano (Department of Pharmaceutical Manufacturing Chemistry, Kyoto Pharmaceutical University) ,  Arimitsu Kenji (Department of Pharmaceutical Manufacturing Chemistry, Kyoto Pharmaceutical University) ,  Kajimoto Tetsuya (Medicinal Organic Chemistry Laboratory, College of Pharmaceutical Sciences, Ritsumeikan University) ,  Hosoi Shinzo (Department of Pharmaceutical Manufacturing Chemistry, Kyoto Pharmaceutical University) ,  Iwasaki Hiroki (Department of Pharmaceutical Manufacturing Chemistry, Kyoto Pharmaceutical University) ,  Kojima Naoto (Department of Pharmaceutical Manufacturing Chemistry, Kyoto Pharmaceutical University) ,  Yamashita Masayuki (Department of Pharmaceutical Manufacturing Chemistry, Kyoto Pharmaceutical University) ,  Kawasaki Ikuo (Department of Medicinal and Synthetic Chemistry, Faculty of Pharmaceutical Sciences, Mukogawa Women’s University)
Material： Chemical and Pharmaceutical Bulletin (Web)
Volume： 67  Issue： 1  Page： 71-74(J-STAGE)  Publication year： 2019 
JST Material Number： U1401A  ISSN： 1347-5223  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： organic compound ,...
Semi thesaurus term： natural organic compound ,...

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Author keywords (8)： stereoselective synthesis ,  E1cB reaction ,  tandem acetylation-E1cB reaction ,  trisubstituted (E)-αβ-unsaturated ester ,  stereoselective synthesis ,  E1cB reaction ,  tandem acetylation-E1cB reaction ,  trisubstituted (E)-αβ-unsaturated ester

JST classification (2)： Aliphatic carboxylic esters,anhydrides,acid halides,acyl peroxides  (CF03210P) ,  Synthesis of drugs  (GV01030F)

Reference (33)：

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• 2) Villa M.-J., Warren S., J. Chem. Soc., Perkin Trans. 1, 1994, 1569 (1994).
• 3) Sturm T., Weissensteiner E., Spindler F., Adv. Synth. Catal., 345, 160-164 (2003).
• 4) Huang J., Corey E. J., Org. Lett., 5, 3455-3458 (2003).
• 5) Langenhan J. M., Gellman S. H., J. Org. Chem., 68, 6440-6443 (2003).

Terms in the title (4)： タンデム ,  アセチル化 ,  置換 ,  不飽和エステル