Art

J-GLOBAL ID：201902262047286954   Reference number：19A2515707

Inhibition of Reactive Astrocytes with Fluorocitrate Ameliorates Learning and Memory Impairment Through Upregulating CRTC1 and Synaptophysin in Ischemic Stroke Rats

フルオロクエン酸による反応性星状細胞の阻害は虚血性脳卒中ラットにおいてCRTC1とシナプトフィチンを上方制御することにより学習と記憶障害を改善する【JST・京大機械翻訳】

Author (11)： Zhang Xinyu (Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, Jiangsu Key Laboratory of Neuropsychiatric Diseases, The Second Affiliated Hospital of Soochow University, Institute of Neuroscience, Soochow University, Suzhou, China) ,  Shen Xianzhi (Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, Jiangsu Key Laboratory of Neuropsychiatric Diseases, The Second Affiliated Hospital of Soochow University, Institute of Neuroscience, Soochow University, Suzhou, China) ,  Dong Jiali (Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, Jiangsu Key Laboratory of Neuropsychiatric Diseases, The Second Affiliated Hospital of Soochow University, Institute of Neuroscience, Soochow University, Suzhou, China) ,  Liu Wen-Cao (Department of Emergency, Shanxi Provincial People’s Hospital, Taiyuan, China) ,  Song Min (Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, Jiangsu Key Laboratory of Neuropsychiatric Diseases, The Second Affiliated Hospital of Soochow University, Institute of Neuroscience, Soochow University, Suzhou, China) ,  Sun Yanyun (Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, Jiangsu Key Laboratory of Neuropsychiatric Diseases, The Second Affiliated Hospital of Soochow University, Institute of Neuroscience, Soochow University, Suzhou, China) ,  Shu Hui (Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, Jiangsu Key Laboratory of Neuropsychiatric Diseases, The Second Affiliated Hospital of Soochow University, Institute of Neuroscience, Soochow University, Suzhou, China) ,  Towse Clare-Louise (School of Chemistry and Biosciences, University of Bradford, Bradford, UK) ,  Liu Wenlan (The Central Laboratory, Shenzhen Second People’s Hospital, Shenzhen University 1st Affiliated Hospital, Shenzhen University School of Medicine, Shenzhen, China) ,  Liu Chun-Feng (Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, Jiangsu Key Laboratory of Neuropsychiatric Diseases, The Second Affiliated Hospital of Soochow University, Institute of Neuroscience, Soochow University, Suzhou, China) ,  Jin Xinchun (Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, Jiangsu Key Laboratory of Neuropsychiatric Diseases, The Second Affiliated Hospital of Soochow University, Institute of Neuroscience, Soochow University, Suzhou, China)
Material： Cellular and Molecular Neurobiology
Volume： 39  Issue： 8  Page： 1151-1163  Publication year： 2019 
JST Material Number： W0158A  ISSN： 0272-4340  CODEN： CMNEDI  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Ischemic stroke often causes m...

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Thesaurus term： *rat ,  *ischemia ,  dysfunction ,  immunostaining ,  Western blotting ,  *cerebral apoplexy ,  glia cell ,  *memory disorder ,  communication ,  hippocampus ,  *astrocyte ,  reperfusion ,  gap junction
Semi thesaurus term： シナプトフィシン ,  認知障害 , 【Automatic Indexing@JST】

Author keywords (6)： Fluorocitrate ,  Reactive astrocytes ,  Cx43 ,  Memory ,  CRTC1 ,  Ischemic stroke

JST classification (5)： Enzyme in general  (EB09010D) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Immunological reaction in general  (ED03010T) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Terms in the title (8)： フルオロクエン酸 ,  反応性 ,  星状細胞 ,  阻害 ,  虚血性脳卒中 ,  ラット ,  上方制御 ,  学習と記憶障害