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J-GLOBAL ID：201902262470960361   Reference number：19A0501603

High-throughput single-molecule RNA imaging analysis reveals heterogeneous responses of cardiomyocytes to hemodynamic overload

高スループット単一分子RNAイメージング解析は心筋細胞の血行動態過負荷に対する不均一応答を明らかにする【JST・京大機械翻訳】

Author (25)： Satoh Masahiro (Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan) ,  Satoh Masahiro (Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan) ,  Nomura Seitaro (Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan) ,  Nomura Seitaro (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Harada Mutsuo (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Yamaguchi Toshihiro (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Ko Toshiyuki (Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan) ,  Ko Toshiyuki (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Sumida Tomokazu (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Toko Haruhiro (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Naito Atsuhiko T. (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Takeda Norifumi (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Tobita Takashige (Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan) ,  Tobita Takashige (Department of Cardiology, Tokyo Women’s Medical University, Tokyo, Japan) ,  Fujita Takanori (Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan) ,  Ito Masamichi (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Fujita Kanna (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Ishizuka Masato (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Kariya Taro (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Akazawa Hiroshi (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Kobayashi Yoshio (Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan) ,  Morita Hiroyuki (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Takimoto Eiki (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Aburatani Hiroyuki (Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan) ,  Komuro Issei (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan)
Material： Journal of Molecular and Cellular Cardiology  (J Mol Cell Cardiol)
Volume： 128  Page： 77-89  Publication year： 2019 
JST Material Number： E0538A  ISSN： 0022-2828  CODEN： JMCDAY  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The heart responds to hemodyna...

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Thesaurus term： *RNA ,  gene expression ,  cardiac hypertrophy ,  *hemodynamics ,  *cardiac myocyte ,  heart ,  mitochondria ,  cardiac insufficiency ,  *overload ,  mouse(animal) ,  time course ,  gene ,  fetus
Semi thesaurus term： 単一細胞 ,  *単一分子 , 【Automatic Indexing@JST】

Author keywords (4)： Heart failure ,  Single-cell spatial analysis ,  Immunostaining ,  Single-molecule fluorescence in situ hybridization

JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Heart  (EJ04020D)

Terms in the title (10)： 高スループット ,  単一分子 ,  RNA ,  イメージング ,  解析 ,  心筋細胞 ,  血行動態 ,  過負荷 ,  不均一 ,  応答