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J-GLOBAL ID：201902262528235231   Reference number：19A1861467

Sac1 Phosphoinositide Phosphatase Regulates Foam Cell Formation by Modulating SR-A Expression in Macrophages

マクロファージにおいてSac1ホスホイノシチドホスファターゼはSR-A発現調節により泡沫細胞形成を調節する

Author (7)： Nigorikawa Kiyomi (Graduate School of Biomedical & Health Sciences, Hiroshima University) ,  Matsumura Takuma (Graduate School of Biomedical & Health Sciences, Hiroshima University) ,  Sakamoto Hiromi (Graduate School of Biomedical & Health Sciences, Hiroshima University) ,  Morioka Shin (Graduate School of Biomedical & Health Sciences, Hiroshima University) ,  Kofuji Satoshi (Graduate School of Biomedical & Health Sciences, Hiroshima University) ,  Takasuga Shunsuke (Department of Pathology and Immunology, Akita University School of Medicine) ,  Hazeki Kaoru (Graduate School of Biomedical & Health Sciences, Hiroshima University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 6  Page： 923-928(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *macrophage ,...
Semi thesaurus term： cell physiology ,...

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Author keywords (12)： Sac1 ,  phosphoinositide phosphatase ,  scavenger receptor A (SR-A) ,  lipid droplet ,  foam cell formation ,  macrophage ,  Sac1 ,  phosphoinositide phosphatase ,  scavenger receptor A (SR-A) ,  lipid droplet ,  foam cell formation ,  macrophage

JST classification (1)： Cell physiology in general  (EF02010S)

Reference (21)：

• 1) Nemoto Y, Kearns BG, Wenk MR, Chen H, Mori K, Alb JG Jr, De Camilli P, Bankaitis VA. Functional characterization of a mammalian Sac1 and mutants exhibiting substrate-specific defects in phosphoinositide phosphatase activity. J. Biol. Chem., 275, 34293-34305 (2000).
• 2) Rohde HM, Cheong FY, Konrad G, Paiha K, Mayinger P, Boehmelt G. The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex. J. Biol. Chem., 278, 52689-52699 (2003).
• 3) Liu Y, Boukhelifa M, Tribble E, Morin-Kensicki E, Uetrecht A, Bear JE, Bankaitis VA. The Sac1 phosphoinositide phosphatase regulates Golgi membrane morphology and mitotic spindle organization in mammals. Mol. Biol. Cell, 19, 3080-3096 (2008).
• 4) Blagoveshchenskaya A, Cheong FY, Rohde HM, Glover G, Knödler A, Nicolson T, Boehmelt G, Mayinger P. Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1. J. Cell Biol., 180, 803-812 (2008).
• 5) Cheong FY, Sharma V, Blagoveshchenskaya A, Oorschot VM, Brankatschk B, Klumperman J, Freeze HH, Mayinger P. Spatial regulation of Golgi phosphatidylinositol-4-phosphate is required for enzyme localization and glycosylation fidelity. Traffic, 11, 1180-1190 (2010).

Terms in the title (6)： マクロファージ ,  ホスホイノシチドホスファターゼ ,  Sr ,  発現 ,  調節 ,  泡沫細胞