Art

J-GLOBAL ID：201902262646603600   Reference number：19A1944367

Presynaptic Dysfunction in Neurons Derived from Tay-Sachs iPSCs

Tay-Sachs IPSC由来ニューロンにおけるシナプス前機能障害【JST・京大機械翻訳】

Author (10)： Matsushita Kozo (Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan) ,  Matsushita Kozo (Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Numakawa Tadahiro (Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan) ,  Odaka Haruki (Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan) ,  Kajihara Ryutaro (Department of Biomedical Laboratory Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Soga Minami (Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan) ,  Ozasa Shiro (Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Nakamura Kimitoshi (Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Mizuta Hiroshi (Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Era Takumi (Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan)
Material： Neuroscience
Volume： 414  Page： 128-140  Publication year： 2019 
JST Material Number： T0919A  ISSN： 0306-4522  CODEN： NRSCDN  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Tay-Sachs disease (TSD) is a G...

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Thesaurus term： oxidative stress ,  characterization ,  neural transmission ,  up-regulation ,  cell death ,  *synapse ,  exocytosis ,  lysosome ,  *neuron ,  *dysfunction ,  effectiveness
Semi thesaurus term： 神経分化 ,  リソソーム膜蛋白質1 ,  神経変性 ,  ガングリオシドGM2 , 【Automatic Indexing@JST】

Author keywords (3)： induced pluripotent stem cells ,  experimental model ,  Tay-Sachs disease

JST classification (1)： Central nervous system  (EJ12030F)

Terms in the title (4)： IPSC ,  ニューロン ,  シナプス ,  機能障害