Art

J-GLOBAL ID：201902262659653014   Reference number：19A0788539

Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells

ゲノム構成とクロマチン分析は発生B細胞における加齢の特徴としてのインシュリン様成長因子シグナル伝達の転写ダウンレギュレーションを同定する【JST・京大機械翻訳】

Author (32)： Koohy Hashem (Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK) ,  Koohy Hashem (Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK) ,  Bolland Daniel J. (Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK) ,  Bolland Daniel J. (Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK) ,  Matheson Louise S. (Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK) ,  Matheson Louise S. (Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK) ,  Schoenfelder Stefan (Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK) ,  Stellato Claudia (Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK) ,  Dimond Andrew (Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK) ,  Varnai Csilla (Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK) ,  Chovanec Peter (Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK) ,  Chovanec Peter (Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK) ,  Chessa Tamara (Signalling, Babraham Institute, Cambridge, UK) ,  Denizot Jeremy (Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK) ,  Denizot Jeremy (Present address: Universite Clermont Auvergne, Inserm U1071, M2iSH, USC-INRA 2018, Clermont-Ferrand, France) ,  Garcia Raquel Manzano (Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK) ,  Wingett Steven W. (Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK) ,  Wingett Steven W. (Bioinformatics, Babraham Institute, Cambridge, UK) ,  Freire-Pritchett Paula (Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK) ,  Freire-Pritchett Paula (Division of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge, UK) ,  Nagano Takashi (Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK) ,  Hawkins Phillip (Signalling, Babraham Institute, Cambridge, UK) ,  Stephens Len (Signalling, Babraham Institute, Cambridge, UK) ,  Elderkin Sarah (Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK) ,  Spivakov Mikhail (Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK) ,  Spivakov Mikhail (Functional Gene Control Group, MRC London Institute of Medical Sciences (LMS), London, UK) ,  Fraser Peter (Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK) ,  Fraser Peter (Department of Biological Science, Florida State University, FL, USA) ,  Corcoran Anne E. (Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK) ,  Corcoran Anne E. (Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK) ,  Varga-Weisz Patrick D. (Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK) ,  Varga-Weisz Patrick D. (School of Biological Sciences, University of Essex, Colchester, UK)
Material： Genome Biology (Web)
Volume： 19  Issue： 1  Page： 126  Publication year： 2018 
JST Material Number： U7384A  ISSN： 1474-760X  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Aging is characterized by loss...

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Thesaurus term： precursor (substance) ,  promoter (genetics) ,  Up-Regulation ,  *Down-Regulation ,  steric conformation ,  gene expression ,  three dimension ,  interaction ,  Bone Marrow ,  chromosome ,  senile change ,  *chromatin ,  Phenotype ,  MicroRNAs ,  histone modification ,  molecular genetic phenomenon

JST classification (1)： Gene expression  (EC02040Q)

Reference (87)：

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• Blood; Insulin-like growth factor-1 potentiates expansion of interleukin-7-dependent pro-B cells; LF Gibson, D Piktel, KS Landreth; 82; 1993; 3005-3011; citation_id=CR3
• Eur J Immunol.; Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo; L Erlandsson, S Licence, F Gaspal, P Lane, AE Corcoran, I-L Mårtensson; 35; 2005; 1969-1976; 10.1002/eji.200425821; citation_id=CR4
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Terms in the title (10)： ゲノム構成 ,  クロマチン ,  分析 ,  B細胞 ,  加齢 ,  インシュリン様成長因子 ,  シグナル伝達 ,  転写 ,  ダウンレギュレーション ,  同定